Cannabinoid-Related Compounds for Medical Use
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioactive Lipids".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 35037
Special Issue Editors
Interests: cannabinoids/endocannabinoids and related bioactive lipids; obesity; metabolism; adipogenesis; lipid and glucose metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: role of bioactive lipids such as endocannabinoids and pro resolving lipid mediators in metabolic and oncological disease; development of cannabinoid-based therapeutic applications in oncological and neurological diseases; role of cell bioenergetics and metabolic phenotypes in disease progression
Interests: cannabinoids; TRP channels; PPAR receptors; rare skeletal muscle diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cannabinoid receptor CB1 was so named as it was identified as the pharmacological target directing the main psychoactive effects of the cannabis-derived phytocannabinoid delta 9-tetrahydrocannabinol (THC). However, while the THC–CB1 ligand–receptor interaction is the canonical cannabinoid signaling pathway, THC is a polypharmacological agent, which we now know is able to modulate the activity of various receptors, channels and enzymes. Additionally, the cannabis plant produces a plethora of THC-related phytocannabinoids, each with (poly)pharmacological proprieties. Therefore, cannabis is a source of many compounds, with some being more abundant than others, that have received great attention owing to their potential therapeutic proprieties, as evidenced by the historical use of cannabis to treat a variety of ailments including epilepsy, pain, cancer, inflammation etc.
To date, only the phytocannabinoids THC and cannabidiol (CBD) have obtained approval from regulatory bodies as therapeutic agents for a limited number of maladies; however, a flourishing body of research suggests that other cannabinoids have clinical potential for many diseases as well. Moreover, some phytocannabinoids are known to directly or indirectly target proteins including receptors and metabolic enzymes of the endocannabinoid system (ECS), whose fine-tuning activity is known to control numerous physiological and pathophysiological processes.
This Special Issue, titled “Cannabinoid-Related Compounds for Medical Use”, will highlight recent developments in medical research on the application of phytocannabinoids, endocannabinoids and their congeners as well as pharmacological agents mimicking their activity.
Dr. Cristoforo Silvestri
Dr. Alessia Ligresti
Dr. Fabio Arturo Iannotti
Guest Editors
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Keywords
- cannabis
- cannabinoid
- phytocannabinoid
- endocannabinoids
- cannabinoid pharmacology
- medical research
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