Bioanalytical Strategies and Practices for Antibody-Drug Conjugates
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 13976
Special Issue Editors
Interests: drug discovery; toxicology; molecular pharmacology; vaccine; medical immunology; bioanalysis; pharmacokinetics; pharmacodynamics
Special Issue Information
Dear Colleagues,
Antibody–drug conjugates (ADCs) consisting of a cytotoxic drug (payload) covalently bound to an antibody by a linker are one of the most promising types of therapeutics particularly for cancers. The antibodies in ADCs scarcely have antitumor activities by themselves, but rather serve as delivery vehicles of payloads by way of their specificity to target antigens. The toxic payloads used in ADCs are either microtubule disruptors or DNA-damaging agents, which are potent enough after release to destroy the target cancer cells. To date, around 14 ADCs have been approved by U.S.Food and Drug Administration (FDA) and more than 100 ADCs are in active clinical development.
ADCs are generated by chemical crosslinking, hybridoma technology, or genetic engineering. The high complexity of ADCs has created significant bioanalytical challenges. Especially in biomatrices, both the small-molecule payloads and the protein portion need to be analyzed. In addition, drug-to-antibody ratio which may dynamically change in vivo is an important parameter better to be analyzed. Finally, linker-derived molecules, digested proteins, as well as all other potentially-present specific degradable molecules may need to be analyzed as well, which brings further challenges for bioanalysis.
This special issue contains a series of papers with topics covering from structures, nomenclature, generation strategies, mechanisms of action, to development of pharmacokinetic and immunogenicity assays for bioanalysis of ADCs. The assay designs that reflect bioanalytical considerations are undoubtedly the highlights of the whole issue.
Prof. Dr. Likun Gong
Prof. Dr. Qiuping Qin
Guest Editors
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Keywords
- antibody-drug conjugate (ADC)
- antidrug antibodies (ADA)
- drug antibody ratio (DAR)
- liquid chromatography-mass spectrometry (LC-MS)
- ligand-binding assays (LBA)
- bioanalytical
- immunogenicity
- neutralizing antibody
- total antibody
- payload
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