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Synthesis of Nanomaterials and Their Applications in Biomedicine—2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 998

Special Issue Editor


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Guest Editor
School of Health Sciences, Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: nanomedicine; nanotechnology; biomaterials; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the great success of the first edition of this Special Issue, we are pleased to announce the launch of the second edition of “Synthesis of Nanomaterials and Their Applications in Biomedicine” in Molecules.

https://www.mdpi.com/journal/molecules/special_issues/77VWSHE367

Advances in nanoscience have been greatly beneficial to biomedicine, enabling the development of innovative nanomaterials, hybrid nanocomposites, multifunctional materials, and 3D-printed structures enhanced with nanoparticles for both diagnosis or therapeutic applications.

This Special Issue is concerned with the synthesis of nanomaterials and their applications in biomedicine, including the development of organic and inorganic nanomaterials with the potential to be used for biomedical applications. Thus, Topics for this Special Issue may include synthesis procedures, physicochemical characterization, and interactions of various nanomaterials with biological systems. Special attention will be given to photodynamic and photothermal applications, theranostic approaches, and bioimaging.

Both original manuscripts and reviews are welcome

Dr. Nefeli Lagopati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomaterials
  • synthesis
  • characterization
  • diagnosis
  • treatment
  • cytotoxicity
  • biocompatibility

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Published Papers (1 paper)

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Research

22 pages, 7241 KB  
Article
Osteogenic Differentiation in Chitosan-Based Scaffolds via P28 and VEGF Delivery
by Keran Zhou, Bianca Simonassi-Paiva, Robert Pogue, Emma Murphy, Zhi Cao, Margaret Brennan Fournet and Declan M. Devine
Molecules 2025, 30(17), 3645; https://doi.org/10.3390/molecules30173645 (registering DOI) - 7 Sep 2025
Abstract
Repairing large bone defects remains a significant clinical challenge due to the limitations of current treatments, including infection risk, donor site morbidity, and insufficient vascularization. The autograft is still the gold standard for large bone defects. In this study, we developed chitosan-based (CS-based) [...] Read more.
Repairing large bone defects remains a significant clinical challenge due to the limitations of current treatments, including infection risk, donor site morbidity, and insufficient vascularization. The autograft is still the gold standard for large bone defects. In this study, we developed chitosan-based (CS-based) scaffolds, incorporating with hydroxyapatite (HAp) and fluorapatite (FAp) ceramics, fabricated by UV crosslinking and freeze-drying, and loaded with P28 peptide, alone or in combination with vascular endothelial growth factor (VEGF), to evaluate the effect of dual bioactive factor delivery. We hypothesized that CS-based scaffolds would optimize ceramic composition and co-delivery of P28 and VEGF, and can enhance early-stage osteogenic differentiation and support bone regeneration. The CS-based scaffolds were characterized by their physicochemical properties, including swelling behavior, mechanical strength, porosity, and in vitro degradation. Biological evaluations were performed including cell proliferation assays, ALP activity, ARS staining, and RT-qPCR, to assess osteogenic differentiation. The results showed that the scaffolds had high porosity, excellent swelling behavior, and degraded within 8 weeks. Dual delivery of P28 and VEGF significantly enhanced early osteogenic markers, indicating a complementary effect. These findings demonstrated that CS-based scaffolds with an optimized ceramic ratio and bioactive factor incorporation have the potential to facilitate bone regeneration. Full article
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