New Therapeutic Tools Against MDR Tumors: Discovery, Synthesis and Evaluation of Bioactive Compounds: 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 115
Special Issue Editors
Interests: anticancer and anti-neurodegenerative agents; self-assembled nanoparticles; liposomal nanovectors; bioconjugates; hybrids
Special Issues, Collections and Topics in MDPI journals
Interests: small organic molecules; natural products; anticancer and antibacterial agents; multitarget inhibitors; hybrids; bioconjugates
Special Issues, Collections and Topics in MDPI journals
Interests: green and sustainable enzymatic reactions; synthetic methodologies to obtain bioactive molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With the success of the initial volume of the Special Issue entitled "New Therapeutic Tools Against MDR Tumors: Discovery, Synthesis and Evaluation of Bioactive Compounds", published in 2025 with ten papers, the editorial team encouraged us to introduce a second volume on the same topic.
Multidrug resistance (MDR) is a major obstacle of clinical treatment, resulting from different defensive mechanisms in cancer. Many reversal agents have been developed through collaboration between synthetic/medicinal chemists and biologists to circumvent MDR. There is currently a plethora of synthetic strategies to help researchers in building molecular libraries, often with templates directly inspired by nature. Therefore, there is a fundamental need for new methods to prepare new and powerful bioactive compounds to treat MDR tumors.
In this Special Issue, we wish to focus on the most recent research efforts toward the discovery of lead compounds and the development of drug candidates for successful therapies against multidrug resistance (MDR) tumors. Special attention will be given to interdisciplinary studies on novel therapeutic agents targeting specific receptors, enzymes, or cellular pathways related to MDR.
Original research articles, reviews, and focus papers are welcome. We aim to collect the most recent insights and results on new and straightforward synthetic approaches to bioactive organic compounds, the preparation of molecular templates for combinatorial chemistry, and the application of computational methods for the rational design and synthesis of novel lead drug candidates, with a focus on fighting MDR tumors.
Dr. Antonia Antoniou
Prof. Dr. Constantinos Athanassopoulos
Dr. Michail Christodoulou
Guest Editors
Manuscript Submission Information
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Keywords
- cancer chemotherapy
- multi-drug resistance (MDR)
- design and synthesis of MDR reversing agents
- structure-activity relationship studies
- MDR active targeting
- hybrids and conjugates
- drug repurposing
- modulators/inhibitors of MDR transporters
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