Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.1
Journals
Microorganisms
Sections
Feature Papers in Antimicrobial Agents and Resistance
share announcement

Feature Papers in Antimicrobial Agents and Resistance

A topical collection in Microorganisms (ISSN 2076-2607). This collection belongs to the section "Antimicrobial Agents and Resistance".

Viewed by 343

Editor

Prof. Dr. Maurizio Ciani

E-Mail Website
Collection Editor
Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy
Interests: non-conventional yeasts; wine yeast; antimicrobial compounds; fermented beverages; killer yeasts
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

This Topical Collection aims to collect high-quality review papers and original research articles on all fields associated with antimicrobial agents and resistance.

In this regard, there has been growing interest in the use of natural antimicrobial compounds to limit or avoid chemical antimicrobial use. Natural antimicrobial compounds have potential applications in the food industry and in the biological control of plant pathogens, as well as applications as agents against animal and human infections.

Antimicrobial resistance is considered a worldwide burden, affecting patients in critical hospital wards, such as intensive care units (ICUs). Hospitalized patients face an increased risk of developing infections due to exposure to invasive devices. Careful clinical surveillance and the monitoring of the bacterial strains responsible for inducing Hospital-Acquired Infections (HAI), as well as the knowledge of antibiotic resistance, may help clinicians to choose appropriate antibiotic therapies. We encourage researchers to contribute review papers (preferably full-length comprehensive reviews) and original research articles highlighting the latest developments in antimicrobial agents and resistance.

Prof. Dr. Maurizio Ciani
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance
  • antimicrobial agents
  • multidrug-resistant bacteria
  • one health approach
  • AMR detection
  • environmental antibiotic residues
  • global health security

Published Papers (1 paper)

2025

11 pages, 3126 KiB  
Article
Increased Expression of AbcA Efflux Pump Accelerated Resistance Development from Tolerance to Resistance Against Oxacillin in Staphylococcus aureus
by Xiaohui Yu, Miaomiao Liu, Pilong Liu, Zehua Hao, Lili Zhao and Xin Zhao
Microorganisms 2025, 13(5), 1140; https://doi.org/10.3390/microorganisms13051140 - 16 May 2025
Viewed by 40
Abstract
Bacterial tolerance, especially in Staphylococcus aureus (S. aureus), may arise under intermittent antibiotic regimens and act as a stepping stone toward resistance development. However, the transition from tolerance to resistance and its contributing factors remain poorly understood. This study explores the [...] Read more.
Bacterial tolerance, especially in Staphylococcus aureus (S. aureus), may arise under intermittent antibiotic regimens and act as a stepping stone toward resistance development. However, the transition from tolerance to resistance and its contributing factors remain poorly understood. This study explores the role of the efflux pump gene abcA in this process. abcA mutants (overexpression, knockout, and complementation) were constructed via homologous recombination. These strains were subjected to 21 cycles of intermittent exposure to oxacillin at 20× MIC, and the resistance evolution was monitored. Spontaneous mutation frequencies and survival abilities in these mutants were also measured to determine their involvement in resistance development. The abcA overexpression mutant exhibited a faster development of resistance compared to the wildtype strain. Conversely, the abcA knockout mutant maintained susceptibility to oxacillin, with no significant changes in the relative MIC. Increased mutation frequency and enhanced survival were observed in the overexpression strain, whereas both were reduced in the knockout. abcA overexpression significantly accelerated the development of oxacillin resistance in S. aureus by promoting spontaneous mutations and bacterial survival. Disrupting abcA may offer a novel strategy to prevent the evolution of antibiotic resistance. Full article
►▼ Show Figures

Graphical abstract

Back to TopTop