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Micromachines
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Dielectrophoresis in Microfluidics
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Dielectrophoresis in Microfluidics

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 12872

Special Issue Editor

Prof. Dr. Khashayar Khoshmanesh

E-Mail Website
Guest Editor
School of Engineering, RMIT University, City Campus, Melbourne, VIC 3001, Australia
Interests: microfluidics; lab-on-a-chip; organ-on-a-chip; mechanobiology; soft matter
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dielectrophoresis, the induced motion of polarizable particles in response to non-uniform electric fields, enables the rapid, label-free and selective manipulation of micro/nano scale particles in microfluidic systems. Thanks to these advantages, dielectrophoresis has been widely used for various applications in physics, chemistry, engineering and biology. For instance, dielectrophoresis enables the controlled focusing and assembly of particles, facilitating their detection and characterization, as well as providing unique opportunities for creation of reconfigurable electronic and optical devices. Likewise, dielectrophoresis enables sorting, assembly and immobilization of target bio-particles to be interfaced with various physical and chemical stimuli and imaged with different microscopic techniques. Advances have been made in this field, by devising novel microelectrode configurations and operating strategies, and more importantly by exploring new exciting applications in the fields of materials and biological sciences.
Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments for the design, fabrication, and utilization of dielectrophoresis in microfluidic platforms, with particular interest being paid to techniques for cellular assays, drug discovery, tissue engineering, nanomaterials, and electronic/optical devices.
We look forward to receiving your submissions!

Dr. Khashayar Khoshmanesh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cellular assays
  • Molecular assays
  • Diagnostics
  • Drug discovery
  • Tissue engineering
  • Lab on a chip
  • Nanomaterials
  • Electronic/optical devices

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Published Papers (2 papers)

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Research

16 pages, 3102 KiB  
Article
Analytical Formulation of the Electric Field Induced by Electrode Arrays: Towards Automated Dielectrophoretic Cell Sorting
by Vladimir Gauthier, Aude Bolopion and Michaël Gauthier
Micromachines 2017, 8(8), 253; https://doi.org/10.3390/mi8080253 - 17 Aug 2017
Cited by 17 | Viewed by 5458
Abstract
Dielectrophoresis is defined as the motion of an electrically polarisable particle in a non-uniform electric field. Current dielectrophoretic devices enabling sorting of cells are mostly controlled in open-loop applying a predefined voltage on micro-electrodes. Closed-loop control of these devices would enable to get [...] Read more.
Dielectrophoresis is defined as the motion of an electrically polarisable particle in a non-uniform electric field. Current dielectrophoretic devices enabling sorting of cells are mostly controlled in open-loop applying a predefined voltage on micro-electrodes. Closed-loop control of these devices would enable to get advanced functionalities and also more robust behavior. Currently, the numerical models of dielectrophoretic force are too complex to be used in real-time closed-loop control. The aim of this paper is to propose a new type of models usable in this framework. We propose an analytical model of the electric field based on Fourier series to compute the dielectrophoretic force produced by parallel electrode arrays. Indeed, this method provides an analytical expression of the electric potential which decouples the geometrical factors (parameter of our system), the voltages applied on electrodes (input of our system), and the position of the cells (output of our system). Considering the Newton laws on each cell, it enables to generate easily a dynamic model of the cell positions (output) function of the voltages on electrodes (input). This dynamic model of our system is required to design the future closed-loop control law. The predicted dielectrophoretic forces are compared to a numerical simulation based on finite element model using COMSOL software. The model presented in this paper enables to compute the dielectrophoretic force applied to a cell by an electrode array in a few tenths of milliseconds. This model could be consequently used in future works for closed-loop control of dielectrophoretic devices. Full article
(This article belongs to the Special Issue Dielectrophoresis in Microfluidics)
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14 pages, 4261 KiB  
Article
Assessment of Sub-Micron Particles by Exploiting Charge Differences with Dielectrophoresis
by Maria F. Romero-Creel, Eric Goodrich, Danielle V. Polniak and Blanca H. Lapizco-Encinas
Micromachines 2017, 8(8), 239; https://doi.org/10.3390/mi8080239 - 2 Aug 2017
Cited by 22 | Viewed by 6375
Abstract
The analysis, separation, and enrichment of submicron particles are critical steps in many applications, ranging from bio-sensing to disease diagnostics. Microfluidic electrokinetic techniques, such as dielectrophoresis (DEP) have proved to be excellent platforms for assessment of submicron particles. DEP is the motion of [...] Read more.
The analysis, separation, and enrichment of submicron particles are critical steps in many applications, ranging from bio-sensing to disease diagnostics. Microfluidic electrokinetic techniques, such as dielectrophoresis (DEP) have proved to be excellent platforms for assessment of submicron particles. DEP is the motion of polarizable particles under the presence of a non-uniform electric field. In this work, the polarization and dielectrophoretic behavior of polystyrene particles with diameters ranging for 100 nm to 1 μm were studied employing microchannels for insulator based DEP (iDEP) and low frequency (<1000 Hz) AC and DC electric potentials. In particular, the effects of particle surface charge, in terms of magnitude and type of functionalization, were examined. It was found that the magnitude of particle surface charge has a significant impact on the polarization and dielectrophoretic response of the particles, allowing for successful particle assessment. Traditionally, charge differences are exploited employing electrophoretic techniques and particle separation is achieved by differential migration. The present study demonstrates that differences in the particle’s surface charge can also be exploited by means of iDEP; and that distinct types of nanoparticles can be identified by their polarization and dielectrophoretic behavior. These findings open the possibility for iDEP to be employed as a technique for the analysis of submicron biological particles, where subtle differences in surface charge could allow for rapid particle identification and separation. Full article
(This article belongs to the Special Issue Dielectrophoresis in Microfluidics)
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