Emerging Research on Molecular Sensors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C:Chemistry".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 624

Special Issue Editors


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Guest Editor
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Interests: micro/nanomotors; biosensors; microfluidics; biomimetic materials; enzymatic catalysis

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Guest Editor
Department of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, China
Interests: microwave biosenosr and gas sensor; micro-scale microwave sensor design and fabrication technology; microfluid-combined microwave sensor chip
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Guest Editor
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Building 9, 1113 Sofia, Bulgaria
Interests: organic synthesis; benzimidazoles; polyphenols; neurodegenerative disorders; neuroprotection; antioxidant activity; free radical scavengers; lipid peroxidation; oxidative stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Molecular sensors are integrated receptor-transducer devices, which can convert molecular responses into external signals based on different approaches. The orchestration and development of molecular sensors are of primary importance for applications such as biosensing, gas sensing, and chemical sensing. Representative challenges in this field include the improvement of transducer performance, such as “3S+3R”, i.e., Sensitivity, Selectivity, Stability, Reproducibility, Response time, and Recovery time. To overcome the limitations of traditional analytical approaches and establish new methodologies, different techniques have been extensively explored to address the scientific and technical challenges in this area.

Hence, in this Special issue, we aim to further explore various emerging techniques in molecular sensing, such as artificial intelligence, micro/nanomotors, microwave, microbalance, microfluidics, electrochemistry, photochemistry, and their combinations, focusing on the fundamental mechanism updates of traditional techniques and attempts to explore novel advanced analytical techniques.

Relevant submissions for this Special Issue include, but are not limited to, the following topics based on the above-mentioned techniques:

  • Design of novel analytical micro/nanomotors-based molecular sensing platforms;
  • Dopamine-related molecule design and synthesis towards moleulcar recogniation;
  • Design of novel nanomaterials towards the enhancement of key parameters in molecular sensing performance, such as “3S+3R”;
  • Emerging Techniques and Fundamental Analysis of microwave sensors, electrochemical sensors, and photochemical sensors;
  • Combination of Artificial Intelligence (AI) with sensing techniques

Prof. Dr. Lei Wang
Dr. Tian Qiang
Dr. Neda Anastassova
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gas sensors
  • micro/nanomotors
  • biosensors
  • cancer cell detection
  • DNA detection
  • molecular sensor
  • dopamine

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Published Papers (1 paper)

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Research

16 pages, 3545 KiB  
Communication
Incubation of Horseradish Peroxidase near 50 Hz AC Equipment Promotes Its Disaggregation and Enzymatic Activity
by Yuri D. Ivanov, Ivan D. Shumov, Andrey F. Kozlov, Alexander N. Ableev, Angelina V. Vinogradova, Ekaterina D. Nevedrova, Oleg N. Afonin, Dmitry D. Zhdanov, Vadim Y. Tatur, Andrei A. Lukyanitsa, Nina D. Ivanova, Evgeniy S. Yushkov, Dmitry V. Enikeev, Vladimir A. Konev and Vadim S. Ziborov
Micromachines 2025, 16(3), 344; https://doi.org/10.3390/mi16030344 - 19 Mar 2025
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Abstract
Low-frequency electromagnetic fields, induced by alternating current (AC)-based equipment such as transformers, are known to influence the physicochemical properties and function of enzymes, including their catalytic activity. Herein, we have investigated how incubation near a 50 Hz AC autotransformer influences the physicochemical properties [...] Read more.
Low-frequency electromagnetic fields, induced by alternating current (AC)-based equipment such as transformers, are known to influence the physicochemical properties and function of enzymes, including their catalytic activity. Herein, we have investigated how incubation near a 50 Hz AC autotransformer influences the physicochemical properties of horseradish peroxidase (HRP), by atomic force microscopy (AFM) and spectrophotometry. We found that a half-hour-long incubation of the enzyme above the coil of a loaded autotransformer promoted the adsorption of the monomeric form of HRP on mica, enhancing the number of adsorbed enzyme particles by two orders of magnitude in comparison with the control sample. Most interestingly, the incubation of HRP above the switched-off transformer, which was unplugged from the mains power supply, for the same period of time was also found to cause a disaggregation of the enzyme. Notably, an increase in the activity of HRP against ABTS was observed in both cases. We hope that the interesting effects reported will emphasize the importance of consideration of the influence of low-frequency electromagnetic fields on enzymes in the design of laboratory and industrial equipment intended for operation with enzyme systems. The effects revealed in our study indicate the importance of proper shielding of AC-based transformers in order to avoid the undesirable influence of low-frequency electromagnetic fields induced by these transformers on humans. Full article
(This article belongs to the Special Issue Emerging Research on Molecular Sensors)
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