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Micromachines
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Point-of-Care Diagnostic Devices
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Point-of-Care Diagnostic Devices

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (10 July 2022) | Viewed by 6108

Special Issue Editor

Dr. Hesam Babahosseini

E-Mail Website
Guest Editor
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Interests: microfluidics; point-of-care diagnostic; chips

Special Issue Information

Dear Colleagues,

POC diagnostic devices are very convenient for continuous monitoring of analytes near the patient. The current COVID-19 pandemic clearly showed the importance of POC diagnostic devices for rapid disease diagnosis and monitoring. The scope of this Special Issue includes any research utilizing micro-engineering technologies and life sciences for the development of a POC device for a rapid diagnostic and screening. 

Dr. Hesam Babahosseini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Portable POC diagnostic devices
  • Microfluidic POC diagnostic devices
  • POC molecular diagnostic devices
  • Smartphone-based POC diagnostic devices
  • Disposable POC diagnostic devices

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Published Papers (2 papers)

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11 pages, 1443 KiB  
Article
Loop-Mediated Isothermal Amplification as Point-of-Care Testing for EGFR-Mutated Lung Adenocarcinoma
by Yuichi Saito, Atsuka Matsui, Satoru Michiyuki, Hiroaki Morooka, Takayuki Ibi, Yoshikane Yamauchi, Nobumasa Takahashi, Yoshihiko Shimizu, Tomohiko Ikeya, Eishin Hoshi, Yukinori Sakao and Masafumi Kawamura
Micromachines 2022, 13(6), 897; https://doi.org/10.3390/mi13060897 - 6 Jun 2022
Cited by 4 | Viewed by 2808
Abstract
Liquid biopsy has been adapted as a diagnostic test for EGFR mutations in patients with advanced or metastatic non-small cell lung cancer (NSCLC). Loop-mediated isothermal amplification (LAMP) has been widely used for the rapid detection of pathogens through DNA amplification. This study investigated [...] Read more.
Liquid biopsy has been adapted as a diagnostic test for EGFR mutations in patients with advanced or metastatic non-small cell lung cancer (NSCLC). Loop-mediated isothermal amplification (LAMP) has been widely used for the rapid detection of pathogens through DNA amplification. This study investigated the efficacy of an EGFR-LAMP assay using plasma samples of patients with resected NSCLC tumors. The EGFR status was investigated using both LAMP and next-generation sequencing (NGS) assays in cases that met the following criteria: (1) pulmonary adenocarcinoma with EGFR mutation detected by the Therascreen EGFR PCR Kit and (2) preoperative plasma samples contained enough DNA for the LAMP and NGS experiments. Among 51 specimens from patients with EGFR-mutated tumors or metastatic lymph nodes, the LAMP assay detected 1 EGFR mutation that was also detected in the NGS assay. However, a plasma sample that demonstrated EGFR wild type in the LAMP assay showed an EGFR mutant status in NGS. The detection rates (1.9% in LAMP and 3.9% in NGS) were very low in both assays, demonstrating a similar performance in detecting EGFR mutations in NSCLC tumors; therefore, it could be a more suitable test for the advanced stage, not the early stage. Notably, the LAMP assay was more time-saving, cost-effective, and straightforward. However, further investigation is required to develop a more sensitive assay. Full article
(This article belongs to the Special Issue Point-of-Care Diagnostic Devices)
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4 pages, 796 KiB  
Case Report
An Assessment of Carotid Flow Time Using a Portable Handheld Ultrasound Device: The Ideal Tool for Guiding Intraoperative Fluid Management?
by Lauren E. Gibson, James E. Mitchell, Edward A. Bittner and Marvin G. Chang
Micromachines 2023, 14(3), 510; https://doi.org/10.3390/mi14030510 - 22 Feb 2023
Cited by 4 | Viewed by 2480
Abstract
Volume resuscitation is a cornerstone of modern anesthesia care. Finding the right balance to avoid inadequate or excess volume administration is often difficult to clinically discern and can lead to negative consequences. Pulse pressure variation is often intraoperatively used to guide volume resuscitation; [...] Read more.
Volume resuscitation is a cornerstone of modern anesthesia care. Finding the right balance to avoid inadequate or excess volume administration is often difficult to clinically discern and can lead to negative consequences. Pulse pressure variation is often intraoperatively used to guide volume resuscitation; however, this requires an invasive arterial line and is generally only applicable to patients who are mechanically ventilated. Unfortunately, without a pulmonary artery catheter or another costly noninvasive device, performing serial measurements of cardiac output is challenging, time-consuming, and often impractical. Furthermore, noninvasive measures such as LVOT VTI require significant technical expertise as well as access to the chest, which may not be practical during and after surgery. Other noninvasive techniques such as bioreactance and esophageal Doppler require the use of costly single-use sensors. Here, we present a case report on the use of corrected carotid flow time (ccFT) from a portable, handheld ultrasound device as a practical, noninvasive, and technically straightforward method to assess fluid responsiveness in the perioperative period, as well as the inpatient and outpatient settings. Full article
(This article belongs to the Special Issue Point-of-Care Diagnostic Devices)
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