3D Bioprinting and Biofabrication Technologies for Tissue Engineering

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B2: Biofabrication and Tissue Engineering".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1386

Special Issue Editor

Special Issue Information

Dear Colleagues,

Three-dimensional (3D) bioprinting is an innovative technology, which has received growing attention from researchers all over the world, mainly because of its wide range of biomedical applications. Recent advancements in biofabrication technologies have driven outstanding innovations in the area of bioengineering, biology, regenerative medicines, and medical device. In particular, bioprinting have been employed to create various biomaterials and print tissue and organ models, significantly accelerating progress in tissue engineering. Nevertheless, properties of engineered living constructs are still far from replicating those of native tissues and organs, mainly due to the inherent complexity and the requirement for a substantial number of cells to create functional organs.

This Special Issue covers bioinks and novel biofabrication systems, 3D printed tissues (organs, bone, cartilage, blood vessels, skin, muscle, etc.), biomaterial formulations, and other relevant topics. Review articles, communications, and research papers that focus on novel developments related to 3D bioprinting and biofabrication technologies are all welcome.

Prof. Dr. Yi Zhang
Guest Editor

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Keywords

  • biofabrication
  • biomaterials
  • 3D bioprinting
  • tissue engineering
  • bioink
  • scaffolds

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Published Papers (1 paper)

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Review

19 pages, 2742 KB  
Review
Integration of Fibroblast-Populated Collagen Lattices and Perfusable Micro-Physiological Systems: A Mechanobiologically Unified Framework for Living Devices
by Kawmini Appuhami, Aya Nakamura-Norimoto and Yasuyuki S. Kida
Micromachines 2026, 17(2), 171; https://doi.org/10.3390/mi17020171 - 28 Jan 2026
Viewed by 840
Abstract
This review proposes mechanical crosstalk between stromal tension and vascular shear/flow as a unifying principle for integrating fibroblast-populated collagen lattices (FPCLs) with perfusable micro-physiological systems (MPSs). We argue that current in vitro platforms either emphasize fibroblast-driven matrix contraction (as with FPCLs) or flow-mediated [...] Read more.
This review proposes mechanical crosstalk between stromal tension and vascular shear/flow as a unifying principle for integrating fibroblast-populated collagen lattices (FPCLs) with perfusable micro-physiological systems (MPSs). We argue that current in vitro platforms either emphasize fibroblast-driven matrix contraction (as with FPCLs) or flow-mediated vascular dynamics (as with MPSs) but rarely consider the reciprocity between these forces. By defining a mechanobiological framework that couples cellular contractility, extracellular matrix (ECM) remodeling, and shear-dependent endothelial responses, we reframe FPCL–MPS hybrids as “living devices” capable of capturing mechano-transduction across stromal and vascular compartments. This review (1) delineates the mechanobiology of FPCLs, highlighting their tension generation, matrix remodeling, and disease relevance; (2) surveys perfusable MPS design principles, focusing on shear stress, barrier function, and multicellular integration; (3) formulates a crosstalk paradigm in which stromal tension and vascular shear coregulate tissue physiology; (4) synthesizes engineering strategies for integrating FPCLs into MPSs; and (5) outlines challenges and future directions involving multiscale measurements, multi-omics, artificial intelligence, and regulatory standardization. To our knowledge, this review is among the first to explicitly frame stromal tension and vascular shear as a unified mechanobiological axis. Full article
(This article belongs to the Special Issue 3D Bioprinting and Biofabrication Technologies for Tissue Engineering)
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