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Micromachines
Special Issues
PCR Chips for Biomarker Discovery and Validation in Drug Development
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PCR Chips for Biomarker Discovery and Validation in Drug Development

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1052

Special Issue Editor

Dr. Kieu The Loan Trinh

E-Mail Website
Guest Editor
Bionano Applications Research Center, Gachon University, Seongnam-si 13120, Republic of Korea
Interests: PCR microfluidics; lab-on-a-chip; system integration; nucleic acid detection; POCT
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomarker research, combined with integrating PCR chip technologies, foresees enormous changes forthcoming in pharmaceutical sciences. This Special Issue, entitled ‘PCR Chips for Biomarker Discovery and Validation in Drug Development’, will highlight the key role that PCR chips play in identifying, validating, and monitoring biomarkers across the life cycle of drug development. Fully integrated PCR chips have enabled precise genetic and molecular biomarker detection and are redefining patient stratification, optimization of therapeutic strategies, and further research on companion diagnostics. The scope of this Special Issue covers cutting-edge topics and research covering the use of PCR chips in pharmacokinetics, pharmacodynamics, predictive biomarker studies, high-throughput screening for resistance biomarkers, and response monitoring in real-time. We also invite the submission of works related to innovations in chip design, miniaturization, and integration with point-of-care platforms. The goal of this Special Issue is to provide an overview of how PCR technologies are going to accelerate drug discovery and enhance personalized medicine approaches. This Special Issue highlights the impact of PCR chip technologies in the identification and validation of biomarkers that drive precision drug development.

We warmly invite researchers, clinicians, and innovators in the discipline to submit your research papers, short communications, and review articles that display your expertise and share your recent findings. Your research will inspire breakthroughs in biomarker-driven therapeutics and influence of the future directions of pharmaceutical sciences.

We look forward to your valuable contributions.

Dr. Kieu The Loan Trinh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PCR chips
  • biomarker discovery
  • biomarker validation
  • drug development
  • predictive biomarkers point-of-care testing
  • molecular diagnostics
  • personalized medicine

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Published Papers (1 paper)

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26 pages, 3046 KiB  
Review
Polymerase Chain Reaction Chips for Biomarker Discovery and Validation in Drug Development
by Dang-Khoa Vo and Kieu The Loan Trinh
Micromachines 2025, 16(3), 243; https://doi.org/10.3390/mi16030243 - 20 Feb 2025
Viewed by 894
Abstract
Polymerase chain reaction (PCR) chips are advanced, microfluidic platforms that have revolutionized biomarker discovery and validation because of their high sensitivity, specificity, and throughput levels. These chips miniaturize traditional PCR processes for the speed and precision of nucleic acid biomarker detection relevant to [...] Read more.
Polymerase chain reaction (PCR) chips are advanced, microfluidic platforms that have revolutionized biomarker discovery and validation because of their high sensitivity, specificity, and throughput levels. These chips miniaturize traditional PCR processes for the speed and precision of nucleic acid biomarker detection relevant to advancing drug development. Biomarkers, which are useful in helping to explain disease mechanisms, patient stratification, and therapeutic monitoring, are hard to identify and validate due to the complexity of biological systems and the limitations of traditional techniques. The challenges to which PCR chips respond include high-throughput capabilities coupled with real-time quantitative analysis, enabling researchers to identify novel biomarkers with greater accuracy and reproducibility. More recent design improvements of PCR chips have further expanded their functionality to also include digital and multiplex PCR technologies. Digital PCR chips are ideal for quantifying rare biomarkers, which is essential in oncology and infectious disease research. In contrast, multiplex PCR chips enable simultaneous analysis of multiple targets, therefore simplifying biomarker validation. Furthermore, single-cell PCR chips have made it possible to detect biomarkers at unprecedented resolution, hence revealing heterogeneity within cell populations. PCR chips are transforming drug development, enabling target identification, patient stratification, and therapeutic efficacy assessment. They play a major role in the development of companion diagnostics and, therefore, pave the way for personalized medicine, ensuring that the right patient receives the right treatment. While this tremendously promising technology has exhibited many challenges regarding its scalability, integration with other omics technologies, and conformity with regulatory requirements, many still prevail. Future breakthroughs in chip manufacturing, the integration of artificial intelligence, and multi-omics applications will further expand PCR chip capabilities. PCR chips will not only be important for the acceleration of drug discovery and development but also in raising the bar in improving patient outcomes and, hence, global health care as these technologies continue to mature. Full article
(This article belongs to the Special Issue PCR Chips for Biomarker Discovery and Validation in Drug Development)
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