Fabrication of Extracellular Matrix Microenvironment with 3D Bioprinting Technology

Dear Colleagues,

Three-dimensional bioprinting technology provides programmable and customizable platforms with which to engineer cell-laden constructs mimicking human tissues for a wide range of biomedical applications. The requirements for an extracellular matrix microenvironment suitable for cell growth are extremely strict. For example, cells require an aqueous environment, sufficient oxygen and nutrient diffusion, and an appropriate pH and osmolarity, along with key vitamins and minerals for cellular functions. Furthermore, certain cell types require specific cell attachment sites and substrate properties to proliferate. Additionally, cells must have room to create a new extracellular matrix, which means that printed materials should degrade into non-toxic components over time to promote new tissue formation. However, considering the complexity of the structures and functions of tissues or organs, it remains a challenge to fabricate an extracellular matrix microenvironment very close to the native environment. It is necessary to employ advanced bioinks with advanced bioprinting technology as a next-generation additive manufacturing technology to fabricate an extracellular matrix microenvironment that maximally emulates its native counterparts. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments in bioink and bioprinting technology related to the fabrication of extracellular matrix microenvironments.

We look forward to receiving your submissions!

Dr. Guoliang Ying
Dr. Nan Jiang
Guest Editors

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