Polymeric Micro/Nano Vectors for Drug Delivery

A special issue of Micro (ISSN 2673-8023). This special issue belongs to the section "Microscale Biology and Medicines".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1610

Special Issue Editors

Center for Advanced Biomaterials for Health Care, Istituto Italiano di Tecnologia (IIT@CRIB), 80125 Naples, Italy
Interests: materials science; drug delivery; micro/nano encapsulation; biomolecule characterization
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy, University of Naples “Federico II”, 80131 Naples, Italy
Interests: peptides; protein-protein interactions; protein dissection; protein and peptides aggregation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last decade, polymeric micro/nano vectors have had a pivotal role in the biomedical field. They can be defined as devices that enable the introduction of a therapeutic compound into the body. Thanks to their flexibility in chemical synthesis, they can be modified for use in both passive and active tissues and cell targeting. In particular, sensitive molecules, such as peptides, proteines and antibodies, can be conjugated on their surface, making it possible to target a single pathological cell, which represents a significant scientific achievement.

This Special Issue will provide a collection of novel research articles and review papers considering the recent development of polymeric drug delivery systems based on natural or synthetic polymers. Moreover, sensitive vectors for active cell targeting will be discussed. Combining perspectives from synthetic and biological fields alike, this issue will provide a new paradigm for the design of polymeric drug delivery systems.

Dr. Concetta Di Natale
Dr. Sara La Manna
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Research

13 pages, 1699 KiB  
Article
Electrochemical Characterization of Nanoporous Alumina-Based Membranes with Different Structure and Geometrical Parameters by Membrane Potential Analysis
by Virginia Romero and Juana Benavente
Micro 2022, 2(3), 475-487; https://doi.org/10.3390/micro2030029 - 27 Jul 2022
Viewed by 1264
Abstract
Electrochemical characterization of alumina-based membranes obtained by two different techniques, sinterization or anodization, is performed by analyzing membrane potential values. This analysis allows us the estimation of the effective concentration of fixed charge in the membrane (Xef) and the transport number [...] Read more.
Electrochemical characterization of alumina-based membranes obtained by two different techniques, sinterization or anodization, is performed by analyzing membrane potential values. This analysis allows us the estimation of the effective concentration of fixed charge in the membrane (Xef) and the transport number of the ions into the pores (ti), as well as the determination of ionic permselectivity (P(i)) and their correlation with the different structures (supported, symmetrical or asymmetric), geometrical parameters (pore size and porosity) and surface materials (alumina-zirconia or alumina) of the studied membranes. From these results, the electropositive character of the membranes was stated, but also the significant reduction (70%) in Xef value and around 30% in permselectivity when pore size increases from 25 nm to 100 nm, in the case of sinterized alumina-zirconia membranes with similar porosity (CRF samples), while the clear influence of pore size on the electrochemical behavior of the electrochemically synthesized alumina membranes (NPAM samples) was confirmed as well as the lower influence of membrane porosity. Moreover, the effect of protein (BSA) static fouling on electrochemical parameters for both CRF and NPAMs samples was also analyzed, and our results show a reduction in the electropositive character of both membranes, being this behavior opposite to that discussed for one of the NPAMs as a result of surface modification with a theophylline derivative (Theo 1). Full article
(This article belongs to the Special Issue Polymeric Micro/Nano Vectors for Drug Delivery)
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