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Metals
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Metal-Containing Nanoparticles for Biomedical Applications
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Metal-Containing Nanoparticles for Biomedical Applications

A special issue of Metals (ISSN 2075-4701). This special issue belongs to the section "Biobased and Biodegradable Metals".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 6781

Special Issue Editor

Prof. Dr. Svetlana Saikova

E-Mail Website1 Website2
Guest Editor
Siberian Federal University, Krasnoyarsk, Russian Federation
Interests: nanochemistry; technology of inorganic materials; synthesis of nanomaterials; sorption
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoparticles for biomedical applications is a rapidly growing field. Over the last few decades, there has been a significant increase in such biomedical applications as cell and tissue imaging, targeted and localized drug delivery, biosensing technologies, photothermal therapy, magnetic hyperthermia for cancer therapy, etc. The most popular nanoparticles include particles for optical imaging (fluorescent quantum dots); gold nanoparticles which contribute to direct heat-mediated cytotoxicity, magnetic nanoparticles manipulated via externally applied magnetic fields to control their behavior, carbon nanomaterials, mesoporous silica nanoparticles, сerium oxide nanoparticles (a potent redox modulator), and polymeric nanoparticles. Nanoparticles for medical use must be biocompatible, nontoxic, and stable in a biological environment. These characteristics can be improved by functionalization of their surface, which also expands the area for their application. This Special Issue will therefore highlight different biomedical applications of nanoparticles. We are interested in articles that explore the design and synthesis of different kinds of nanoparticles, manipulation of their size, shape, properties, and functional groups, as well as opportunities and strategies for their successful clinical applications. Resent research projects addressing novel characterization protocols, the way nanoparticles interact with the biological environment and/or their toxicity, hazards, and biodistribution will also be of great interest.

Prof. Dr. Svetlana Saikova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • biomedical applications
  • magnetic hyperthermia
  • photothermal therapy
  • design and synthesis
  • toxicity
  • biodistribution
  • gold
  • iron oxides
  • rare earth oxides

Published Papers (2 papers)

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Research

18 pages, 36096 KiB  
Article
Hybrid Nanoparticles Based on Cobalt Ferrite and Gold: Preparation and Characterization
by Svetlana Saikova, Alexander Pavlikov, Tatyana Trofimova, Yuri Mikhlin, Denis Karpov, Anastasiya Asanova, Yuri Grigoriev, Mikhail Volochaev, Alexander Samoilo, Sergey Zharkov and Dmitry Velikanov
Metals 2021, 11(5), 705; https://doi.org/10.3390/met11050705 - 25 Apr 2021
Cited by 12 | Viewed by 3197
Abstract
During the past few decades, hybrid nanoparticles (HNPs) based on a magnetic material and gold have attracted interest for applications in catalysis, diagnostics and nanomedicine. In this paper, magnetic CoFe2O4/Au HNPs with an average particle size of 20 nm, [...] Read more.
During the past few decades, hybrid nanoparticles (HNPs) based on a magnetic material and gold have attracted interest for applications in catalysis, diagnostics and nanomedicine. In this paper, magnetic CoFe2O4/Au HNPs with an average particle size of 20 nm, decorated with 2 nm gold clusters, were prepared using methionine as a reducer and an anchor between CoFe2O4 and gold. The methionine was used to grow the Au clusters to a solid gold shell (up to 10 gold deposition cycles). The obtained nanoparticles (NPs) were studied by X-Ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FT-IR) spectroscopy, X-Ray photoelectron spectroscopy (XPS) and UV-vis spectroscopy techniques. The TEM images of the obtained HNPs showed that the surface of cobalt ferrite was covered with gold nanoclusters, the size of which slightly increased with an increase in the number of gold deposition cycles (from 2.12 ± 0.15 nm after 1 cycle to 2.46 ± 0.13 nm after 10 cycles). The density of the Au clusters on the cobalt ferrite surface insignificantly decreased during repeated stages of gold deposition: 21.4 ± 2.7 Au NPs/CoFe2O4 NP after 1 cycle, 19.0 ± 1.2 after 6 cycles and 18.0 ± 1.4 after 10 cycles. The magnetic measurements showed that the obtained HNPs possessed typical ferrimagnetic behavior, which corresponds to that of CoFe2O4 nanoparticles. The toxicity evaluation of the synthesized HNPs on Chlorella vulgaris indicated that they can be applied to biomedical applications such as magnetic hyperthermia, photothermal therapy, drug delivery, bioimaging and biosensing. Full article
(This article belongs to the Special Issue Metal-Containing Nanoparticles for Biomedical Applications)
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13 pages, 3916 KiB  
Article
Synthesis and Characterization of Core–Shell Magnetic Nanoparticles NiFe2O4@Au
by Diana Saykova, Svetlana Saikova, Yuri Mikhlin, Marina Panteleeva, Ruslan Ivantsov and Elena Belova
Metals 2020, 10(8), 1075; https://doi.org/10.3390/met10081075 - 10 Aug 2020
Cited by 15 | Viewed by 2991
Abstract
In this study, NiFe2O4@Au core–shell nanoparticles were prepared by the direct reduction of gold on the magnetic surface using amino acid methionine as a reducer and a stabilizing agent simultaneously. The obtained nanoparticles after three steps of gold deposition [...] Read more.
In this study, NiFe2O4@Au core–shell nanoparticles were prepared by the direct reduction of gold on the magnetic surface using amino acid methionine as a reducer and a stabilizing agent simultaneously. The obtained nanoparticles after three steps of gold deposition had an average size of about 120 nm. The analysis of particles was performed by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, and UV-Vis spectroscopy techniques. The results indicate successful synthesis of core–shell particles with the magnetic core, which consists of a few agglomerated nickel ferrite crystals with an average size 25.2 ± 2.0 nm, and the thick gold shell consists of fused Au0 nanoparticles (NPs). Magnetic properties of the obtained nanoparticles were examined with magnetic circular dichroism. It was shown that the magnetic behavior of NiFe2O4@Au NPs is typical for superparamagnetic NPs and corresponds to that for NiFe2O4 NPs without a gold shell. The results indicate the successful synthesis of core–shell particles with the magnetic nickel ferrite core and thick gold shell, and open the potential for the application of the investigated hybrid nanoparticles in hyperthermia, targeted drug delivery, magnetic resonance imaging, or cell separation. The developed synthesis strategy can be extended to other metal ferrites and iron oxides. Full article
(This article belongs to the Special Issue Metal-Containing Nanoparticles for Biomedical Applications)
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