Special Issue "Metabolic Flux Analysis"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (31 August 2015).
Metabolic fluxes are the most important phenotype, and are the end result of the interplay of gene expression, protein expression, enzyme kinetics, and metabolite concentrations. A quantitative representation of this phenotype can be estimated with metabolic flux analysis (MFA), based on either flux balance analysis (FBA), which is obtained via stoichiometric constraints, or 13C-metabolic flux analysis (13C-MFA), which is obtained via stable isotope balances, together with stoichiometric constraints. Accurate information concerning metabolic fluxes is important for both understanding metabolic regulation mechanisms (science) and metabolic engineering applications (engineering).
This Special Issue of Metabolites, “Metabolic Flux Analysis”, will be dedicated not only to the development of the flux analysis method, but also to applications enabling an in-depth understanding of metabolisms or metabolic regulation mechanisms, and of metabolic engineering applications or fermentation improvements (which are achieved through the optimization of culture conditions). Organisms covered include microorganisms (such as E.coli, Yeast, Bacillus, Corynebacteria, Streptomyces, etc.), photosynthetic organisms (such as plant, algae, and cyanobacteria), and mammalian cells (such as mouse, human, and cancer cells). Moreover, this Special Issue also covers systems biology approaches, such as FBA-based modeling (and its extension into genome-scale metabolic modeling) and kinetic modeling.
Prof. Dr. Kazuyuki Shimizu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- metabolic fluxes
- metabolic regulation
- integration of omics data
- flux balance analysis
- kinetic modeling
- genome-scale modeling
- metabolic engineering
- synthetic biology