Recent Developments in Thyroid Hormone Regulation in Metabolic Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 13688
Special Issue Editors
2. Department für Anatomie, Universitätsklinikum Tübingen, 72076 Tübingen, Germany
Interests: development of formulations; assessment of toxic effects on the respiratory system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Today, thyroid diseases have become an interdisciplinary field of general practitioners, internists (endocrinologists, immunologists, oncologists), nuclear medicine specialists including radiation therapists, surgeons, ophthalmologists and other specialties. The use of modern technologies in basic research has enabled more insight into the mode of action of thyroid hormones and their metabolites, resulting in a potential therapeutic use of thyroid hormone metabolites.
One of the main tasks of thyroid hormones is to control important metabolic steps in the organism. Besides goiters with all their adverse effects on the organism, autoimmune diseases are among the most common thyroid diseases today. Abnormal thyroid hormones in particular have been linked to cardiovascular diseases, metabolic syndrome and cancer. This Special Issue aims to better understand the interplay of metabolic disorders and thyroid hormone metabolism, reveal new mechanisms of action and the regulation of thyroid hormones or their metabolites and identify innovative modalities for the treatment of thyroid diseases. The role of thyroid hormones and their metabolites in metabolic disorders, bile acid signaling, insulin sensitivity, hepatic gluconeogenesis, aging, neuro-modulatory effects and the immune system is still not entirely clear. Further, additional insight is needed into the regulation via the TRH–TSH–thyroid axis by nutritional signals.
We would like to encourage submissions (original articles, reviews, commentaries) on new findings related to normal and dysregulated thyroid metabolism.
Prof. Dr. Eleonore Fröhlich
Prof. Dr. Richard Wahl
Guest Editors
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Keywords
- T3, T4, TRH and TSH
- PPAR, liver X receptor
- bile acid
- insulin, insulin resistance, gluconeogenesis
- brown fat, white fat
- leptin, ghrelin
- inflammatory markers
- epigenetics and molecular biology
- bone metabolism
- cardiovascular effects
- NAFLD/MAFLD
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