Obesity and Associated Comorbidities: Implications for Neural and Immune Regulation of Energy Metabolism

Dear Colleagues,

The brain modulates several aspects of metabolism, integrating metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy, glucose and lipid homeostasis.

Defective crosstalk between the brain and peripheral organs contributes to the development of metabolic disorders, namely obesity and type 2 diabetes. This Special Issue highlights the brain’s regulation of energy metabolism. Specific areas include, but are not limited to, the identification of molecular mechanisms of hypothalamic regulation of food intake, energy expenditure and liver metabolism, the role of microbiota and the gut–brain axis in energy homeostasis, obesity-induced neuroinflammation and dysregulation of brain metabolism, and molecular targets for obesity treatment. Manuscripts dealing with other pertinent challenging issues are also highly encouraged.

Dr. Joana M. Gaspar
Dr. Natalia F. Mendes
Dr. Silvia Ravera
Guest Editors

Manuscript Submission Information

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