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Special Issue "Mitochondrial Metabolism and Bioenergetics"
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 29865
Special Issue Editors
Interests: bioenergetics; mitochondrial metabolism; TCA cycle; mitochondrial control of cell physiology; neurodegeneration; immunometabolism
Interests: isotope tracing; metabolic flux analysis; de novo lipogenesis; metabolomics; lipidomics; metabolic syndrome and associated diseases; breastmilk production and function
Special Issue Information
Historically, the study of mitochondria has largely relied on biochemical techniques, including enzymology, oxygen consumption, and absorption or fluorescence spectroscopy to characterize these remarkable organelles. However, metabolomics and stable isotope tracing have now emerged as additional front-line techniques which have considerably aided our understanding of the role of mitochondria in cell function. Additionally, new methodologies such as compartment-specific isotope tracing and rapid isolation of mitochondria in combination with mass spectrometry techniques have allowed measurements of mitochondrial metabolism to be distinguished from other cellular compartments. Combining these techniques with classic bioenergetic measurements such as respirometry has highlighted the importance of mitochondrial metabolism in fields including immunology, cancer, metabolic disease, and neurodegeneration.
This Special Issue centers on the study of mitochondrial metabolism using metabolomics and stable isotope tracing. We invite original articles on mitochondrial metabolism, as well as reviews highlighting the roles of mitochondrially-derived metabolites in healthy physiology and disease. In addition, we strongly encourage methods-focused manuscripts describing compartment-specific analysis to disentangle changes between mitochondrial metabolism and its broader cellular environment. All areas of physiology and disease are welcome provided they address the selected topic. Specific topics may include but are by no means limited to: regulation of TCA cycle metabolism, lipidomic studies of mitochondria, and mitochondrial handling of amino acids, fatty acids, or nucleotides and co-factors (e.g., NAD+ or CoA esters). Manuscripts that highlight how information gained from mass spectrometry or NMR-based approaches can be interpreted alongside classical mitochondrial techniques are also encouraged.
Dr. Ajit Divakaruni
Dr. Martina Wallace
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mass spectrometry
- TCA cycle
- oxidative phosphorylation