Brain Substrate Metabolism in Health and Disease

Dear Colleagues,

In recent decades, we have been facing a global epidemic of obesity, with its prevalence having tripled in the last four decades. Currently, more than 1.9 billion people are overweight, and over 650 million people are obese. Several research lines have shown that in the context of obesity and insulin resistance, brain glucose and free fatty acid uptake are altered. Some reports have also suggested that an altered brain metabolism in the context of systemic insulin resistance may contribute to further worsening of whole-body homeostasis.

On the other hand, brain glucose metabolism alterations are also well described in the context of mild cognitive impairment and Alzheimer’s disease, while it seems that metabolic and neurologic disorders may share common pathophysiologic pathways. Neuroimaging (PET, MRI, fMRI, MRS, MEG) provides unique opportunities to study the human brain non-invasively. This Special Issue welcomes studies performed in humans assessing brain substrate metabolism (assessed with neuroimaging) in the context of metabolic and neurologic disorders. Preclinical research which may shed more light in the brain findings into these disease is also welcome.

Dr. Eleni Rebelos
Guest Editor

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