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Metabolites
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Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome
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Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 7118

Special Issue Editors

Dr. Alina Delia Popa

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Guest Editor
Nursing Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: prenatal care; nutrients; obstetrics; diabetes; nursing
Special Issues, Collections and Topics in MDPI journals
Dr. Otilia Nita

E-Mail Website
Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Grigore T Popa” Iasi, 700115 Iasi, Romania
Interests: diabetes; metabolic syndrome; nutrition; insulin resistance; sleep apnea
Dr. Lidia Iuliana Arhire

E-Mail Website
Guest Editor
Department of Medical Specialties (II), Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania
Interests: obesity; diabetes; metabolic syndrome; nutrition; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mariana Graur

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Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
Interests: diabetes; metabolism; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background. Metabolic syndrome aggregates diseases sharing the same pathophysiological pathways: insulin resistance, hyperinsulinemia, chronic low-grade inflammation, and neurohormonal activation. The definition of metabolic syndrome has varied since it was first described by Reaven in 1988, but the diagnostic criteria have always included central obesity, dysglycemia, high blood pressure, hypertriglyceridemia, and hypo-HDL cholesterolemia. Metabolic syndrome helps identify individuals with high cardiovascular risk, which is higher than the sum of cardiovascular risk given by each component. With the increasing prevalence of obesity, metabolic syndrome is also rising alarmingly, adding to the immense cardiovascular burden. At present, even if the diagnosis is made by having any three criteria out of five, it is considered a multifaceted condition, which includes fatty liver disease, obstructive sleep apnea, procoagulant status, microbiota changes and even cognitive impairment. The therapy of metabolic syndrome should be a holistic approach to its components. Lifestyle interventions are key therapeutic strategies for metabolic syndrome, and aim to enhance the effects of pharmacotherapy. 

Aims. This Special Issue of Metabolites on “Lifestyle Interventions: A Challenging Therapeutic Strategy for Metabolic Syndrome” focuses on potential lifestyle interventions that may influence metabolic syndrome and its components. Studies on dietary interventions (dietary patterns, circadian time feeding, intermittent fasting, use of supplements, nutraceuticals, and functional foods), physical activity, sleep (sleep apnea, circadian sleep disorders (sleep deprivation, sleep length, night shifts, jet lag)), microbiota changes through either diet or sleep interventions and nutritional interactions with medical therapy will be considered. Original research articles as well as reviews and meta-analyses related to topics including but not limited to those mentioned above will be considered for peer review.

Dr. Alina Delia Popa
Dr. Otilia Nita
Dr. Lidia Iuliana Arhire
Prof. Dr. Mariana Graur
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

16 pages, 601 KiB  
Article
Lifestyle Patterns in Patients with Type 2 Diabetes
by Andreea Gherasim, Andrei C. Oprescu, Ana Maria Gal, Alexandra Maria Burlui and Laura Mihalache
Metabolites 2023, 13(7), 831; https://doi.org/10.3390/metabo13070831 - 9 Jul 2023
Cited by 1 | Viewed by 1630
Abstract
Modern lifestyles have led to sedentary behavior, lower participation in active movement and physical activities during leisure time, unhealthy diets, and increased exposure to stress. It is important to examine the interaction of several lifestyle risk factors instead of focusing on one alone. [...] Read more.
Modern lifestyles have led to sedentary behavior, lower participation in active movement and physical activities during leisure time, unhealthy diets, and increased exposure to stress. It is important to examine the interaction of several lifestyle risk factors instead of focusing on one alone. The purpose of this study was to identify lifestyle patterns in a group of patients with type 2 diabetes and the associations of its components with certain metabolic parameters. Using principal component analysis, we identified three dietary patterns: the prudent pattern (fat, oil, cereals, potatoes, vegetables, fish, nuts, seeds and fruits), the Western pattern (meat and meat products, eggs and soft drinks) and the traditional pattern (milk and its derivatives, soups and sauces, with a low intake of sugar/snacks). In addition, using the same method of analysis, we identified two lifestyle patterns: the inadequate lifestyle pattern (Western dietary pattern, increased hours of sleep and lower levels of stress) and the traditional lifestyle pattern (traditional dietary pattern, increased physical activity (PA) and non-smoking status). The inadequate lifestyle pattern was associated with younger age, hypertension and diabetic neuropathy. The traditional lifestyle pattern was related to lower postprandial blood glucose levels. Sedentary individuals were more likely to be over 65 years old and to have higher glycated hemoglobin (HbA1c). Smokers were also more likely to have inadequate glycemic and lipid profile control. Full article
(This article belongs to the Special Issue Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome)
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11 pages, 398 KiB  
Article
The Influence of Metabolic Factors in Patients with Chronic Viral Hepatitis C Who Received Oral Antiviral Treatment
by Oana Irina Gavril, Radu Sebastian Gavril, Florin Mitu, Otilia Gavrilescu, Iolanda Valentina Popa, Diana Tatarciuc, Andrei Drugescu, Andrei Catalin Oprescu, Andreea Gherasim, Laura Mihalache and Irina Mihaela Esanu
Metabolites 2023, 13(4), 571; https://doi.org/10.3390/metabo13040571 - 17 Apr 2023
Cited by 1 | Viewed by 1621
Abstract
Hepatic diseases pose a significant public health concern. Regardless of the severity of hepatic fibrosis, treatment is recommended for all chronic hepatitis C virus (HCV) subjects. However, fibrosis and steatosis assessment remains crucial for evaluating the prognosis, progression, and hepatic disease monitoring, particularly [...] Read more.
Hepatic diseases pose a significant public health concern. Regardless of the severity of hepatic fibrosis, treatment is recommended for all chronic hepatitis C virus (HCV) subjects. However, fibrosis and steatosis assessment remains crucial for evaluating the prognosis, progression, and hepatic disease monitoring, particularly following the treatment with direct-acting antivirals (DAAs). The aim of our study was to evaluate the impact of metabolic factors and the extent of hepatic fibrosis and fat accumulation in chronic HCV infection subjects. Additionally, another objective was to investigate modifications regarding fibrosis and steatosis three months after a successful sustained viral response (SVR). A total of 100 patients with compensated cirrhosis and chronic hepatitis C (CHC) were included in our study. These patients received treatment with DAA and underwent Fibromax assessment before and three months post SVR. After DAA treatment, a significant decrease was observed in the degree of hepatic fibrosis and hepatic steatosis. This regression was evident three months following the achievement of SVR. Chronic viral hepatitis C may trigger risk factors for metabolic syndromes, such as obesity and type 2 diabetes mellitus. Conclusions: It is crucial to monitor metabolic factors and take timely measures to prevent or treat metabolic syndrome in patients with chronic viral hepatitis C. Full article
(This article belongs to the Special Issue Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome)
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13 pages, 283 KiB  
Article
Correlations between Cognitive Evaluation and Metabolic Syndrome
by Andrei Cătălin Oprescu, Cristina Grosu and Walther Bild
Metabolites 2023, 13(4), 570; https://doi.org/10.3390/metabo13040570 - 17 Apr 2023
Cited by 2 | Viewed by 1515
Abstract
One of the most common medical diseases is metabolic syndrome (MetS), which encompasses diabetes and obesity. It has a systemic effect, which has long-lasting consequences on the body that are still not fully understood. The objectives of the study were to investigate the [...] Read more.
One of the most common medical diseases is metabolic syndrome (MetS), which encompasses diabetes and obesity. It has a systemic effect, which has long-lasting consequences on the body that are still not fully understood. The objectives of the study were to investigate the association between the severity of metabolic imbalances, insulin resistance, leptin concentration, and the presence of cognitive disorders and to assess the possible protective role of some classes of drugs used in the treatment of type 2 diabetes mellitus (T2D) and dyslipidemia in order to identify a viable target in the near future. The study included 148 diabetic patients. Standardized tests for the evaluation of cognition, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), were applied to all study participants. Serum concentrations of leptin and insulin were determined using the enzyme-linked immunosorbent assay method (ELISA), and insulin resistance was calculated using the homeostatic model assessment for insulin resistance (HOMA-IR). We found that MMSE and MoCA scores were associated with anthropometric parameters, and MoCA was associated with glycemic control parameters and leptin levels. Further research is needed in order to establish the magnitude of the relationship between metabolic syndrome components and cognitive decline in diabetic patients. Full article
(This article belongs to the Special Issue Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome)
13 pages, 251 KiB  
Article
Dietary Patterns of Patients with Prediabetes and Type 2 Diabetes
by Camelia Oana Iatcu, Ana-Maria Gal and Mihai Covasa
Metabolites 2023, 13(4), 532; https://doi.org/10.3390/metabo13040532 - 7 Apr 2023
Viewed by 1768
Abstract
Given the worldwide high prevalence of type 2 diabetes, the prevention and control of this disease has become an urgent priority. In this research, we report the results from a cross-sectional study conducted in the counties of Suceava and Iasi, northeast of Romania, [...] Read more.
Given the worldwide high prevalence of type 2 diabetes, the prevention and control of this disease has become an urgent priority. In this research, we report the results from a cross-sectional study conducted in the counties of Suceava and Iasi, northeast of Romania, on 587 patients with type 2 diabetes and 264 patients with prediabetes. By employing a factor analysis (principal component) on 14 food groups followed by varimax orthogonal rotation, three dietary patterns were identified for each group. In prediabetes, a low adherence to a specific dietary pattern (1 and 2) was associated with lower fasting plasma glucose, blood pressure and serum insulin, compared to increased adherence. In patients with diabetes, a low adherence to Pattern 1 was associated with lower systolic blood pressures, while a low adherence to Pattern 3 was associated with a lower HbA1c, compared to high adherence. Statistically significant differences between the groups were observed for fats and oils, fish and fish products, fruit, potatoes, sugars, preserves and snacks intake. The study demonstrated that certain food patterns are associated with increased blood pressure, fasting blood glucose and serum insulin. Full article
(This article belongs to the Special Issue Lifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic Syndrome)
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