Lifestyle Interventions: A Challenging Therapeutic Strategy for Metabolic Syndrome 2nd Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 March 2025) | Viewed by 4596

Special Issue Editors


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Guest Editor
Nursing Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: prenatal care; nutrients; obstetrics; diabetes; nursing
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Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
Interests: diabetes; metabolic syndrome; nutrition; insulin resistance; sleep apnea

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Guest Editor
Department of Medical Specialties (II), Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania
Interests: obesity; diabetes; metabolic syndrome; nutrition; insulin resistance
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
Interests: diabetes; metabolism; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background. Metabolic syndrome aggregates diseases sharing the same pathophysiological pathways: insulin resistance, hyperinsulinemia, chronic low-grade inflammation, and neurohormonal activation. The definition of metabolic syndrome has varied since it was first described by Reaven in 1988, but the diagnostic criteria have always included central obesity, dysglycemia, high blood pressure, hypertriglyceridemia, and hypo-HDL cholesterolemia. Metabolic syndrome helps identify individuals with high cardiovascular risk, which is higher than the sum of cardiovascular risk given by each component. With the increasing prevalence of obesity, metabolic syndrome is also rising alarmingly, adding to the immense cardiovascular burden. At present, even if the diagnosis is made by having any three criteria out of five, it is considered a multifaceted condition, which includes fatty liver disease, obstructive sleep apnea, procoagulant status, microbiota changes and even cognitive impairment. The therapy for metabolic syndrome should be a holistic approach to its components. Lifestyle interventions are key therapeutic strategies for metabolic syndrome, and aim to enhance the effects of pharmacotherapy.

Aims. This Special Issue of Metabolites on “Lifestyle Interventions: A Challenging Therapeutic Strategy for Metabolic Syndrome 2nd Edition” focuses on potential lifestyle interventions that may influence metabolic syndrome and its components. Studies on dietary interventions (dietary patterns, circadian time feeding, intermittent fasting, use of supplements, nutraceuticals, and functional foods), physical activity, sleep (sleep apnea, circadian sleep disorders (sleep deprivation, sleep length, night shifts, jet lag)), microbiota changes through either diet or sleep interventions and nutritional interactions with medical therapy will be considered. Original research articles as well as reviews and meta-analyses related to topics including, but not limited to, those mentioned above will be considered for peer review.

Dr. Alina Delia Popa
Dr. Otilia Nita
Dr. Lidia Iuliana Arhire
Prof. Dr. Mariana Graur
Guest Editors

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Keywords

  • diabetes
  • metabolic syndrome
  • insulin resistance
  • obesity

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Published Papers (2 papers)

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Research

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13 pages, 1157 KiB  
Article
Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders
by Barbara Janota, Elżbieta Szczepańska, Kinga Noras and Ewa Janczewska
Metabolites 2023, 13(10), 1033; https://doi.org/10.3390/metabo13101033 - 25 Sep 2023
Cited by 2 | Viewed by 2012
Abstract
The lifestyle causes of metabolic disorders in patients with hypothyroidism should be investigated. We aimed to assess the lifestyle and quality of life of women diagnosed with hypothyroidism and search for the presence of differences between the lifestyle and quality of life of [...] Read more.
The lifestyle causes of metabolic disorders in patients with hypothyroidism should be investigated. We aimed to assess the lifestyle and quality of life of women diagnosed with hypothyroidism and search for the presence of differences between the lifestyle and quality of life of women with and without diagnosed lipid metabolism disorders. This study included 311 women. To assess the differences between the groups with and without metabolic disorders, a non-parametric Mann–Whitney U test was performed. Of the products that were potentially beneficial for health, statistically significant differences in the average frequency of consumption were observed for legume seeds (p = 0.014), and of the products potentially unbeneficial for health, the frequencies of consumption of fried dishes (p = 0.016) and fast-food products (p = 0.001) were significant. Only 11.9% rated their free-time physical activity as high. The quality of life was significantly different between the groups. The lifestyle was moderately appropriate. Compared with women with lipid metabolism disorders, women without them exhibited a higher frequency of correct dietary behaviors regarding the consumption of products with a potentially beneficial effect and sleeping duration. Women without lipid metabolism disorders had a better quality of life. Women with hypothyroidism should be educated about the beneficial aspects of the regular consumption of vegetables, fruits, legumes, and fish and sleeping for the optimal amount of time. Full article
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Review

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23 pages, 382 KiB  
Review
Fasting Mimicking Diet for Metabolic Syndrome: A Narrative Review of Human Studies
by Alina Delia Popa, Andreea Gherasim, Laura Mihalache, Lidia Iuliana Arhire, Mariana Graur and Otilia Niță
Metabolites 2025, 15(3), 150; https://doi.org/10.3390/metabo15030150 - 23 Feb 2025
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Abstract
Metabolic syndrome (MetS) is an association of risk factors that share insulin resistance (IR), exerting a super cumulative effect on the risk of developing cardiometabolic diseases. Lifestyle optimization is a key element in the prevention and non-pharmacological therapy of MetS. Certain studies have [...] Read more.
Metabolic syndrome (MetS) is an association of risk factors that share insulin resistance (IR), exerting a super cumulative effect on the risk of developing cardiometabolic diseases. Lifestyle optimization is a key element in the prevention and non-pharmacological therapy of MetS. Certain studies have concluded that some dietary patterns could be more beneficial as an adjunctive treatment for MetS. Fasting mimicking diet (FMD) is a form of periodic fasting in which caloric intake is restricted for 5 days each month. It has been studied for its beneficial effects not only in patients with neoplasia and neurodegenerative diseases but also for its effects on IR and metabolism. In this narrative review, the effects of FMD in patients with MetS were analyzed, focusing on its impact on key metabolic components and summarizing findings from human studies. FMD has demonstrated beneficial effects on MetS by reducing BMI and waist circumference, preserving lean mass, and improving the metabolic profile. Moreover, individuals with a higher BMI or a greater number of MetS components appear to derive greater benefits from this intervention. However, limitations such as high dropout rates, small sample sizes, and methodological constraints restrict the generalizability of current findings. Further large-scale studies are needed to confirm these effects and establish FMD as a viable non-pharmacological strategy for managing MetS. Full article
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