Novel Research on Membrane Trafficking and Membrane Contact Sites
A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".
Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 6310
Special Issue Editor
Special Issue Information
Dear Colleagues,
Eukaryotic cells are organized into membrane-bound organelles, and their content in terms of lipids and proteins is maintained and regulated by a constant flux of vesicular intermediates. Membrane trafficking is the process that controls the delivery of proteins, sugars, and lipids to all of the organelles. Cell communication with the environment is guaranteed by endocytosis and exocytosis through the continuous exchange of materials. Over the last decade, the membrane trafficking field expanded its horizon through the discovery of novel sites of interaction among organelles: membrane contact sites (MCSs). MCSs are defined as regions where two membranes of two distinct organelles come into close apposition (10 to 30 nm in distance) without fusing, most frequently involving the endoplasmic reticulum (ER) and another organelle. This proximity allows a rapid flux of information, in terms of ions and lipids, tightly mediated by several classes of proteins, including tethering factors, lipid transfer proteins, and ion channels, in a highly dynamic manner. A challenge in the field of membrane trafficking is represented by the identification of novel layers of regulation together with the development of new advanced techniques for the precise study of all involved events. Our understanding of MCS is constantly growing along with knowledge of the molecular machineries responsible for their functioning, but many aspects, including regulation, dynamics, and function, have, so far, remained elusive.
For this Special Issue, we would like to invite you to submit reviews and original research articles further advancing our knowledge in the field of membrane trafficking and membrane contact sites, with a special focus on the use of innovative technological approaches for the study of membrane trafficking and on the recent findings in terms of function, composition, and regulation of membrane contact sites.
Dr. Rossella VendittiGuest Editor
Manuscript Submission Information
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Keywords
- Membrane trafficking
- Membrane contact sites
- Lipid homeostasis
- Phosphoinositides
- Lipid transfer proteins
- Dynamics and regulation of membrane contact sites
- Advanced microscopy and imaging techniques
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