Plasma Membrane Dynamics and Oncogenic Signaling: Emerging Interfaces in Cancer Biology
A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membranes".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 24
Special Issue Editors
Interests: developmental biology; stem cell biology; molecular biology; biochemistry; Xenopus; Zebrafish; lipids; cancer
Interests: developmental biology; molecular biology and genetics; zebrafish; regeneration; Alzheimer; Wnt signaling; lipids
Special Issue Information
Dear Colleagues,
The plasma membrane is a dynamic and highly organized structure that plays a crucial role in regulating various signaling pathways critical for cellular homeostasis. Recent advances in lipidomic and membrane biophysics have elucidated the role of the plasma membrane lipid composition, fluidity, and microdomain organization in regulating oncogenic signaling networks. Dysregulation of lipid metabolism and membrane remodeling is increasingly recognized as a hallmark of cancer, contributing to tumor progression, metastasis, and resistance to therapy.
This Special Issue aims to bring together cutting-edge research exploring the relationship between membrane lipid dynamics and cancer-related signaling pathways and is focused on advancing our understanding of how membrane lipid dynamics change in cancer biology. The insights gained may provide a mechanistic basis for the development of targeted therapeutic strategies directed at membrane components involved in cancer pathogenesis.
We welcome original research articles and comprehensive reviews that address the mechanistic roles of lipid rafts, sphingolipids, and cholesterol-enriched domains in modulating oncogenic signaling pathways, including PI3K/AKT, RAS/MAPK, and Wnt/β-catenin. This Special Issue focuses on lipid–protein interactions, spatial-temporal regulation of the plasma membrane-bound receptors, and the impact of the lipid-targeted therapies on cancer.
Topics of interest include, but are not limited to, the following:
- Lipid raft-mediated regulation of signaling in cancer;
- Crosstalk between lipid metabolism and oncogenic pathways;
- Role of phospholipids and sphingolipids in cancer cell signaling;
- Imaging and biophysical tools to study membrane organization in cancer;
- Lipid-based therapeutic strategies and drug delivery systems;
- Influence of the tumor microenvironment on lipid remodeling;
- Lipid signaling in cancer stem cells and tumor heterogeneity.
We invite contributions from molecular and cancer biologists, lipid researchers, and interdisciplinary scientists.
Dr. Yagmur Azbazdar
Prof. Dr. Gunes Ozhan
Prof. Dr. Christopher R. Murphy
Guest Editors
Manuscript Submission Information
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Keywords
- plasma membrane dynamics
- lipid rafts and microdomains
- oncogenic signaling pathways
- lipid signaling in cancer
- membrane lipid remodeling
- cancer therapeutics targeting lipids
- lipid–protein interactions
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