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Membranes
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Biocompatible Membranes
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Biocompatible Membranes

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 14709

Special Issue Editors

Dr. Maria Helena Casimiro

E-Mail Website
Guest Editor
C2TN, Center for Nuclear Sciences and Technologies, Instituto Superior Técnico, Lisbon University, 2695-066 Bobadela LRS, Portugal
Interests: functionalization and characterization of macromolecular materials; polymeric supporting systems; radiation processing; membrane reactors; biomaterials; skin scaffolds; biomedical applications; environmental applications; conservation and restoration applications
Special Issues, Collections and Topics in MDPI journals
Dr. Luís M. Ferreira

E-Mail Website
Guest Editor
1. C2TN, Center for Nuclear Sciences and Technologies, Instituto Superior Técnico, Lisbon University, 2695-066 Bobadela LRS, Portugal
2. DECN, Department of Nuclear Sciences and Engineering, Instituto Superior Técnico, University Lisbon, 2695-066 Bobadela LRS, Portugal
Interests: processing of advanced macromacromolecular materials by radiation technologies, for biomedical, environmental, fine chemistry and in the conservation/preservation of cultural heritage; charcterization of polymeric-based materials by nuclear techniques

Special Issue Information

Dear Colleagues,

Biocompatible membranes can be highly complex structures: aside from their functional and mechanical properties, their biological compatibility must be assured in order to successfully fulfill their intended use. Whether for biomedical or environmental applications, membranes are dynamic structures that are fundamental to innumerous vital processes.

This Special Issue “Biocompatible Membranes” aims to cover the latest developments and innovations regarding the synthesis, functionalization, characterization and application of biocompatible membranes in distinct areas such as biomedical and environmental fields. It represents a good opportunity for researchers to present their latest work addressing fundamental aspects and also applied research within this field. This issue will also highlight new challenges to achieving more efficient membranes in increasingly demanding and specific applications.

Full articles, short communications or review articles are welcome.

Dr. Maria Helena Casimiro
Dr. Luís M. Ferreira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biocompatible polymeric, hybrid and composite membranes
  • Membrane preparation, functionalization and characterization
  • Instructive membranes
  • Membrane interactions
  • Implantable membranes
  • Membrane delivery systems
  • Membrane-based biosensors and bioreactors
  • Bioprocessing applications
  • Environmental applications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

13 pages, 5116 KiB  
Article
DLC-Coated Ferroelectric Membranes as Vascular Patches: Physico-Chemical Properties and Biocompatibility
by Yuri Yuriev, Semen Goreninskii, Artem Runts, Elisaveta Prosetskaya, Evgenii Plotnikov, Darya Shishkova, Yulia Kudryavtseva and Evgeny Bolbasov
Membranes 2021, 11(9), 690; https://doi.org/10.3390/membranes11090690 - 7 Sep 2021
Cited by 10 | Viewed by 3014
Abstract
In this paper, the results on the fabrication of ferroelectric membranes as vascular patches with modified surfaces are presented. For the modification of a membrane surface contacting blood, DLC coating was deposited using the pulsed vacuum arc deposition technique. The physico-chemical properties and [...] Read more.
In this paper, the results on the fabrication of ferroelectric membranes as vascular patches with modified surfaces are presented. For the modification of a membrane surface contacting blood, DLC coating was deposited using the pulsed vacuum arc deposition technique. The physico-chemical properties and cytotoxicity of the membranes modified under various conditions were studied. It was found that DLC coatings do not affect membrane microstructure, preserving its crystal structure as well as its high strength and elongation. It was revealed that an increase in the capacitor storage voltage results in the rise in sp2- and sp-hybridized carbon concentration, which makes it possible to control the chemical structure and surface energy of the modified surface. The experiments with 3T3L1 fibroblasts showed no toxic effects of the materials extracts. Full article
(This article belongs to the Special Issue Biocompatible Membranes)
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12 pages, 2681 KiB  
Article
Chitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materials for Skin Regeneration
by Maria Helena Casimiro, Andreia Pereira, João P. Leal, Gabriela Rodrigues and Luís M. Ferreira
Membranes 2021, 11(8), 561; https://doi.org/10.3390/membranes11080561 - 26 Jul 2021
Cited by 11 | Viewed by 3249
Abstract
Some of the current strategies for the development of scaffolding materials capable of inducing tissue regeneration have been based on the use of polymeric biomaterials. Chitosan, in particular, due to its recognized biological activity has been used in a number of biomedical applications. [...] Read more.
Some of the current strategies for the development of scaffolding materials capable of inducing tissue regeneration have been based on the use of polymeric biomaterials. Chitosan, in particular, due to its recognized biological activity has been used in a number of biomedical applications. Aiming the development of chitosan-based membranes with improved cell adhesion and growth properties to be used as skin scaffolds allowing functional tissue replacement, different formulations with chitosan of different molecular weight, poly (vinyl alcohol) and gelatin, were evaluated. To meet the goal of getting ready-to-use scaffolds assuring membranes’ required properties and sterilization, preparation methodology included a lyophilization procedure followed by a final gamma irradiation step. Two radiation dose values were tested. Samples were characterized by TGA, FTIR, and SEM techniques. Their hydrophilic properties, in vitro stability, and biocompatibility were also evaluated. Results show that all membranes present a sponge-type inner structure. Chitosan of low molecular weight and the introduction of gelatin are more favorable to cellular growth leading to an improvement on cells’ morphology and cytoskeletal organization, giving a good perspective to the use of these membranes as potential skin scaffolds. Full article
(This article belongs to the Special Issue Biocompatible Membranes)
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16 pages, 7453 KiB  
Article
Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing
by Tamara S. Tverdokhlebova, Ludmila S. Antipina, Valeriya L. Kudryavtseva, Ksenia S. Stankevich, Ilya M. Kolesnik, Evgenia A. Senokosova, Elena A. Velikanova, Larisa V. Antonova, Dmitry V. Vasilchenko, Georgiy T. Dambaev, Evgenii V. Plotnikov, Vyacheslav M. Bouznik and Evgeny N. Bolbasov
Membranes 2021, 11(1), 21; https://doi.org/10.3390/membranes11010021 - 28 Dec 2020
Cited by 7 | Viewed by 3293
Abstract
Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene [...] Read more.
Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds. Full article
(This article belongs to the Special Issue Biocompatible Membranes)
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14 pages, 1860 KiB  
Article
In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes
by Abdu Mansur Dacache Neto, Suelen Cristina Sartoretto, Isabelle Martins Duarte, Rodrigo Figueiredo de Brito Resende, Adriana Terezinha Neves Novellino Alves, Carlos Fernando de Almeida Barros Mourão, Jose Calasans-Maia, Pietro Montemezzi, Gilson Coutinho Tristão and Mônica Diuana Calasans-Maia
Membranes 2020, 10(12), 423; https://doi.org/10.3390/membranes10120423 - 15 Dec 2020
Cited by 21 | Viewed by 3899
Abstract
Mechanical barriers prevent the invasion of the surrounding soft tissues within the bone defects. This concept is known as Guided Bone Regeneration (GBR). The knowledge about the local tissue reaction and the time of degradation of absorbable membranes favors the correct clinical indication. [...] Read more.
Mechanical barriers prevent the invasion of the surrounding soft tissues within the bone defects. This concept is known as Guided Bone Regeneration (GBR). The knowledge about the local tissue reaction and the time of degradation of absorbable membranes favors the correct clinical indication. This study aimed to evaluate the biocompatibility and biodegradation of a bovine collagen membrane (Lyostypt®, São Gonçalo, Brazil) and compare it to a porcine collagen membrane (Bio-Gide®) implanted in the subcutaneous tissue of mice, following ISO 10993-6:2016. Thirty Balb-C mice were randomly divided into three experimental groups, LT (Lyostypt®), BG (Bio-Gide®), and Sham (without implantation), and subdivided according to the experimental periods (7, 21, and 63 days). The BG was considered non-irritant at seven days and slight and moderate irritant at 21 and 63 days, respectively. The LT presented a small irritant reaction at seven days, a mild reaction after 21, and a reduction in the inflammatory response at 63 days. The biodegradation of the LT occurred more rapidly compared to the BG after 63 days. This study concluded that both membranes were considered biocompatible since their tissue reactions were compatible with the physiological inflammatory process; however, the Bio-Gide® was less degraded during the experimental periods, favoring the guided bone regeneration process. Full article
(This article belongs to the Special Issue Biocompatible Membranes)
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