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Medicina
Special Issues
Updates on Risk Factors and Prevention of Coronary Artery Disease
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Updates on Risk Factors and Prevention of Coronary Artery Disease

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 530

Special Issue Editors

Dr. Antoniu Petris

E-Mail Website
Guest Editor
Faculty of Medicine, University of Medicine and Pharmacy Iasi, Iasi, Romania
Interests: echocardiography; coronary artery disease; heart failure; acute pulmonary thromboembolism; intensive care in cardiology
Special Issues, Collections and Topics in MDPI journals
Dr. Valentin Chioncel

E-Mail Website
Guest Editor Assistant
Department of Cardiology, University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania
Interests: cardiology

Special Issue Information

Dear Colleagues,

Despite all our accumulated knowledge, ischemic coronary disease continues to represent one of the most widespread pathologies, with a very high mortality and morbidity. Acquiring detailed knowledge of risk factors and their control is crucial both in the management of this disease and in placing patients in risk groups in order to prevent the occurrence of this pathology or its complications. Thus, to expand on the enormous progress made in diagnosis and therapy in coronary artery disease, it is extremely important that we develop preventive measures and strategies to control this major health problem.

Our main objectives for this Special Issue are to update the knowledge related to the control of risk factors and to discuss the most effective prevention strategies, as well as modern treatment methods, in this very challenging pathology, emphasizing the clinical impacts on patient outcomes.

I welcome original research, reviews, and other types of articles that contribute to our understanding and the advancement of knowledge in the field of coronary artery disease, focusing on the issues listed above.

Dr. Antoniu Petris
Guest Editor

Dr. Valentin Chioncel
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • risk prediction
  • diabetes mellitus
  • hypertension
  • dyslipidemia
  • prevention
  • coronary angioplasty

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Published Papers (1 paper)

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Research

10 pages, 945 KiB  
Article
Prevalence of Severe Hypercholesterolemia and Familial Hypercholesterolemia Phenotype in Patients with Acute Coronary Syndrome
by Urtė Aliošaitienė, Aleksandras Laucevičius, Urtė Smailytė, Egidija Rinkūnienė, Roma Puronaitė, Jūratė Barysienė and Žaneta Petrulionienė
Medicina 2025, 61(4), 681; https://doi.org/10.3390/medicina61040681 - 7 Apr 2025
Viewed by 335
Abstract
Background and Objectives: Atherosclerotic cardiovascular disease is one of the most common causes of death and disability around the world. Hypercholesterolemia is an established and widely prevalent risk factor; however, the prevalence of severe hypercholesterolemia (which is characteristic for familial hypercholesterolemia) has [...] Read more.
Background and Objectives: Atherosclerotic cardiovascular disease is one of the most common causes of death and disability around the world. Hypercholesterolemia is an established and widely prevalent risk factor; however, the prevalence of severe hypercholesterolemia (which is characteristic for familial hypercholesterolemia) has been studied far less. The aim of this study was to determine the prevalence of severe hypercholesterolemia among patients with acute coronary syndrome. Materials and Methods: A retrospective study of patients hospitalised at Vilnius University Hospital Santaros Klinikos due to acute coronary syndrome was performed. Data were attained from an electronic medical history database. Data such as sex, age, cardiovascular risk factors (hypertension, diabetes) and low-density cholesterol results were collected. Severe hypercholesterolemia was defined as low-density lipoprotein cholesterol levels ≥ 4.9 mmol/L. Results: A total of 34,669 patients were included in this study (12,115 females (34.9%) and 22554 (65.1%) males, p < 0.001). The median age of the entire study population was 67 years. A total of 3434 patients (9.9%) had severe hypercholesterolemia, 371 (1.1%) patients met the criteria for phenotypically probable familial hypercholesterolemia, and 36 (0.1%) patients presented with phenotypically definite familial hypercholesterolemia. The most common concomitant risk factor in this study was arterial hypertension, which was found in 48% of patients. Conclusions: Based on the results of this study, severe hypercholesterolemia is prevalent among patients with acute coronary syndrome, with as many as 9.9% of patients presenting with severe hypercholesterolemia at the time of hospitalisation. The definite familial hypercholesterolemia phenotype is scarcer, with prevalence reaching 0.1% of patients with acute coronary syndrome. Full article
(This article belongs to the Special Issue Updates on Risk Factors and Prevention of Coronary Artery Disease)
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