Neurosurgery for Brain or Spine Tumors: Recent Technical Advances

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Neurology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1735

Special Issue Editors


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Guest Editor
Department of Neurosurgery, Józef Struś Multi-Specialty Municipal Hospital, ul. Szwajcarska 3, 61-285 Poznan, Poland
Interests: neurosurgical techniques; spinal surgery; neurooncology; neurodegenerative diseases

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Guest Editor
Department of Neurosurgery, Medical University Innsbruck, 6020 Innsbruck, Austria
Interests: brain tumors; neuro-oncology; spine; aneurysm; neurosurgery; surgery; stereotactic radiosurgery; minimally invasive surger; glioma

Special Issue Information

Dear Colleagues,

This Special Issue, "Neurosurgery for Brain or Spine Tumors: Recent Technical Advances", aims to explore the latest innovations and techniques in neurosurgical treatments for brain and spine tumors. With rapid advancements in technology and surgical methods, this issue will highlight key developments such as minimally invasive procedures, robot-assisted surgeries, and the integration of intraoperative imaging and neuro-navigation systems. It will also focus on the evolving role of precision medicine, genetic and molecular profiling, and novel therapeutic strategies like immunotherapy in the management of brain and spine tumors. Despite technological breakthroughs in these areas, challenges persist in ensuring optimal patient outcomes. This Special Issue seeks to bring together original research, reviews, and case studies to further our understanding of these techniques, their clinical applications, and their impact on survival and quality of life for patients with brain and spine tumors.

Dr. Bartosz Sokół
Dr. Ondra Petr
Guest Editors

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Keywords

  • neurosurgery
  • brain tumors
  • spine tumors
  • minimally invasive surgery
  • robot-assisted surgery
  • neuro-navigation
  • intraoperative imaging
  • precision medicine
  • molecular profiling
  • immunotherapy

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Published Papers (1 paper)

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Research

18 pages, 2074 KB  
Article
EVD-Associated Infections in Subarachnoid Hemorrhage: Risk Factors and Clinical Predictions—A Retrospective Single-Center Study
by Hraq Sarkis, Abed Alrazzak Kerhani, Ann-Kathrin Joerger, Carolin Albrecht, Chiara Negwer, Maria Wostrack, Arthur Wagner and Bernhard Meyer
Medicina 2025, 61(11), 2058; https://doi.org/10.3390/medicina61112058 - 19 Nov 2025
Viewed by 1295
Abstract
Background and Objectives: External ventricular drain (EVD)-associated infections are a serious complication in subarachnoid hemorrhage (SAH) patients, with reported incidence rates of 1–45%. Existing prediction models show limited performance and focus on the static risk factors assessed at insertion, failing to examine how [...] Read more.
Background and Objectives: External ventricular drain (EVD)-associated infections are a serious complication in subarachnoid hemorrhage (SAH) patients, with reported incidence rates of 1–45%. Existing prediction models show limited performance and focus on the static risk factors assessed at insertion, failing to examine how infection risk changes over time. We sought to identify the independent predictors of EVD infections in SAH patients and develop a practical clinical prediction model. Materials and Methods: We retrospectively analyzed 198 SAH patients with EVDs treated at our center between January 2022 and April 2025, collecting 4757 laboratory observations throughout their hospital stay. Univariate and multivariate logistic regression analyses were performed to identify the independent risk factors and develop a clinical prediction model. Results: Of 198 patients undergoing EVD insertion for SAH, 49 developed associated infections (24.7%). Univariate analysis identified several significant risk factors, including EVD duration (Cohen’s d = 1.00, p < 0.001), EVD revisions (d = 1.11, p < 0.001), Hunt & Hess grade ≥ 4 (p = 0.011), and peak laboratory values, including CSF lactate (d = 0.53, AUC = 0.79), CSF protein (d = 0.52, AUC = 0.74), CSF glucose (d = 0.63, AUC = 0.73), and procalcitonin (d = 0.58, AUC = 0.75). However, multivariate analysis revealed that only EVD duration retained statistical significance (adjusted OR = 3.50 per continuous day; 95% CI: 2.11–5.78; p < 0.000001); note that continuous daily scale modeling implies exponential risk escalation (3.5-fold increase per single day). For clinical interpretation, categorical duration analysis provides more conservative estimates: 8–14 days versus ≤7-day reference OR = 1.92 (p = 0.013), and >14 days versus ≤7-day reference OR = 3.70 (p < 0.001). All other variables lost statistical independence after mutual adjustment. Infection rates demonstrated a dose–response relationship with EVD duration: 11.1% for ≤7 days, 19.3% for 8–14 days, and 31.6% for >14 days. The final prediction model achieved good discrimination (AUC = 0.737). Conclusions: EVD duration emerged as the dominant predictor of infection risk in SAH patients, which is a traditional factor. These findings support clinical protocols that prioritize minimizing drain duration whenever medically appropriate, shifting focus from complex risk scoring to time-based management strategies. Full article
(This article belongs to the Special Issue Neurosurgery for Brain or Spine Tumors: Recent Technical Advances)
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