Special Issue "Biomedical Applications of Biodegradable Composites"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editor

Dr. Declan Devine
E-Mail Website
Guest Editor
Material Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co. Westmeath, Ireland
Interests: Polymer; Tissue Engineering; Bone Regeneration; Composites, Additive Manufacturing

Special Issue Information

Dear Colleagues,

The use of biodegradable composites is increasing in the biomedical space. Composites, by their nature, impart the beneficial properties of the individual components while overcoming their limitations through the synergistic combination of distinctly different materials. However, the potential of biodegradable composites can only be achieved if there is intimate, uninterrupted contact between the reinforcement and matrix phases of the composite and in the case of nanocomposites exfoliation of the nanoparticles. This can, in itself, be difficult to achieve while retaining the biocompatibility of the final construct, as the matrix and reinforcement agent are generally not compatible. Approaches for this can include the following:

  • Surface treatment
  • Reactive extrusion
  • Process optimisation

Biodegradable composites can generally be processed using traditional manufacturing techniques but can also utilise emerging technologies such as additive manufacturing to produce final fabricated implants. These enable easy production scaling, which can expediate the uptake of these technologies.

Furthermore, while the biodegradable nature of these composites allows tissue to repair uninterred as the implant degrades, the biocompatibility of the degradation components must be given special consideration.

Nevertheless, these composites can be used to overcome shortfalls of traditional materials in a variety of applications such as:

  • Tissue engineering
  • Bone repair
  • Cardiovascular, urinary, and other stents
  • In-situ controlled release of active pharmaceutical ingredients

Dr. Declan Devine
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biodegradable composites
  • surface treatment
  • nanoreinforcement
  • additive manufacturing
  • cytocompatibility

Published Papers (1 paper)

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Research

Open AccessArticle
Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes
Materials 2019, 12(11), 1830; https://doi.org/10.3390/ma12111830 - 05 Jun 2019
Cited by 4
Abstract
Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based drug delivery system. PLA/HNT nanocomposites have shown immense potential for use in biomedical applications due to their [...] Read more.
Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based drug delivery system. PLA/HNT nanocomposites have shown immense potential for use in biomedical applications due to their favorable cyto- and hemo-compatibility. The objective of this study was to evaluate the release of active pharmaceutical ingredients (API) from PLA/HNT composites matrix and the effect of preloading the API into the lumen of the HNT on its release profile. Aspirin was used in this study as a model drug as it is a common nonsteroidal anti-inflammatory and antiplatelet agent widely used for various medical conditions. These two types of drug-loaded PLA/HNT nanocomposites were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), surface wettability and mechanical testing. Statistical analysis was conducted on numerical data. Drug entrapment and in vitro drug release studies were conducted using UV spectrophotometry. Results indicate that aspirin was successfully loaded into the lumen of HNT, which resulted in the sustained release of aspirin from the nanocomposites. Furthermore, the addition of HNT into the polymer matrix increased the mechanical properties, indicating its suitability as a drug-eluting reinforcing agent. Full article
(This article belongs to the Special Issue Biomedical Applications of Biodegradable Composites)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Precision and strength properties of PLA biodegradable material for producing of dental and orthodontics patterns
Author: Juraj Beniak
Abstract: The PLA material is produced from the natural sources and the biggest advantage comparing to conventional thermoplastic produced from oil is that they are biodegradable. The another advantage is that the PLA material is easy use for 3D printing with low warping, low printing temperature and good strength properties. The PLA material is also suitable as a basic for composite material. Nowadays the PLA plastic material is also used for for preparation of dental and orthodontics patterns for preparation of different medical models. So there is necessity to know the material and accuracy properties of produced models if there are suitable for our application and if the PLA plastic can replace others usually used materials suitable form FDM technology. Presented paper deals with experiments, where the strength of produced specimens is measured and compared to others usual used thermoplastic suitable for FDM additive manufacturing technologies. The second part of presented research is experimental determination of specimen precision produced by FDM printing. They are used different shapes and dimensions and also different software for 3D model slicing and 3D model printing data preparation. All the experiments are statistically evaluated by statistical methods.

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