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Article

Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing

1
Materials Research Institute, Athlone Institute of Technology, N37 HD68 Athlone, Ireland
2
Área do Conhecimento de Ciências Exatas e Engenharias, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul 95070-560, RS, Brazil
3
Instituto de Biotecnologia, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul 95070-560, RS, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editor: Roman Perez Antoñanzas
Materials 2021, 14(11), 2889; https://doi.org/10.3390/ma14112889
Received: 28 April 2021 / Revised: 24 May 2021 / Accepted: 25 May 2021 / Published: 27 May 2021
(This article belongs to the Special Issue Biomedical Applications of Biodegradable Composites)
Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded with ZnONPs green synthesized from Ilex paraguariensis leaves with a spherical shape and ~18 nm diameter size. The fibers were produced using the electrospinning technique and SEM images showed a uniform morphology with a diameter of ~230 nm. EDS analysis proved a consistent dispersion of Zn in the fiber mat, however, particle agglomerates with varying sizes were observed. FTIR spectra confirmed the interaction of PAA carboxylic groups with the amine of PAH molecules. Although ZnONPs presented higher antimicrobial activity against S. aureus than E. coli, resazurin viability assay revealed that the PAA/PAH/ZnONPs composite successfully inhibited both bacteria strains growth. Photomicrographs support these results where bacteria clusters were observed only in the control samples. The PAA/PAH/ZnONPs composite developed presents antimicrobial activity and mimics the extracellular matrix morphology of skin tissue, showing potential for wound healing treatments. View Full-Text
Keywords: zinc oxide nanoparticles; antimicrobial; electrospinning; polymer fiber; wound healing zinc oxide nanoparticles; antimicrobial; electrospinning; polymer fiber; wound healing
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MDPI and ACS Style

Bandeira, M.; Chee, B.S.; Frassini, R.; Nugent, M.; Giovanela, M.; Roesch-Ely, M.; Crespo, J.d.S.; Devine, D.M. Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing. Materials 2021, 14, 2889. https://doi.org/10.3390/ma14112889

AMA Style

Bandeira M, Chee BS, Frassini R, Nugent M, Giovanela M, Roesch-Ely M, Crespo JdS, Devine DM. Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing. Materials. 2021; 14(11):2889. https://doi.org/10.3390/ma14112889

Chicago/Turabian Style

Bandeira, Marina, Bor S. Chee, Rafaele Frassini, Michael Nugent, Marcelo Giovanela, Mariana Roesch-Ely, Janaina d.S. Crespo, and Declan M. Devine. 2021. "Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing" Materials 14, no. 11: 2889. https://doi.org/10.3390/ma14112889

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