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Open AccessArticle

Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes

1
Material Research Institute, Athlone Institute of Technology, Athlone N37 FK59, Ireland
2
Faculty of Engineering and Informatics, Athlone Institute of Technology, Athlone N37 FK59, Ireland
*
Author to whom correspondence should be addressed.
Materials 2019, 12(11), 1830; https://doi.org/10.3390/ma12111830
Received: 8 May 2019 / Revised: 29 May 2019 / Accepted: 3 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Biomedical Applications of Biodegradable Composites)
Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based drug delivery system. PLA/HNT nanocomposites have shown immense potential for use in biomedical applications due to their favorable cyto- and hemo-compatibility. The objective of this study was to evaluate the release of active pharmaceutical ingredients (API) from PLA/HNT composites matrix and the effect of preloading the API into the lumen of the HNT on its release profile. Aspirin was used in this study as a model drug as it is a common nonsteroidal anti-inflammatory and antiplatelet agent widely used for various medical conditions. These two types of drug-loaded PLA/HNT nanocomposites were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), surface wettability and mechanical testing. Statistical analysis was conducted on numerical data. Drug entrapment and in vitro drug release studies were conducted using UV spectrophotometry. Results indicate that aspirin was successfully loaded into the lumen of HNT, which resulted in the sustained release of aspirin from the nanocomposites. Furthermore, the addition of HNT into the polymer matrix increased the mechanical properties, indicating its suitability as a drug-eluting reinforcing agent. View Full-Text
Keywords: Aspirin; polylactic acid; halloysite nanotubes; nanocomposites; active pharmaceutical ingredients; melt extrusion; drug loading; drug delivery Aspirin; polylactic acid; halloysite nanotubes; nanocomposites; active pharmaceutical ingredients; melt extrusion; drug loading; drug delivery
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MDPI and ACS Style

Venkatesh, C.; Clear, O.; Major, I.; Lyons, J.G.; Devine, D.M. Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes. Materials 2019, 12, 1830.

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