Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.8
3.1
Journals
Materials
Special Issues
Advances in Hybrid Biomaterials
materials-logo
Submit to Materials Review for Materials Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Advances in Hybrid Biomaterials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 27180

Special Issue Editor

Prof. Yuzhou Wu

E-Mail Website1 Website2
Guest Editor
1. Huazhong University of Science and Technology, Wuhan, China
2. Max Planck Institute for Polymer Research, Mainz, Germany
Interests: bionanotechnology; biohybrid materials; nanomedicine; regenerative biomaterials

Special Issue Information

Dear Colleagues,

Over the past decade, hybrid biomaterials built up from biomolecules (e.g., peptides, proteins, polysaccharides, DNA/RNA, etc.) and synthetic materials (synthetic polymer, inorganic nanoparticle, metal complex, etc.) have been advancing rapidly with respect to both synthetic strategies and applications. These materials are highly attractive because of the marriage of advantages of both components, such as biocompatibility, biological function, molecular recognition, chirality (biological component) and variety of physical/chemical properties, stability, processability (synthetic component). Preparation of hybrid biomaterials have been explored from a “grafting to” strategy by straightforward conjugation of both entities to “graft from” strategy that even allows direct synthesis of synthetic components from biomolecules. Consequently, the resulting biohybrids have evolved from initial nonspecific and statistical conjugation to more defined chemical and structural control. Such advances in synthetic strategies also significantly broaden the applications of hybrid biomaterials, particularly for nanomedicine, tissue engineering, diagnostics, implantable materials and wearable devices.

In this context, the main focus of the forthcoming Special Issue entitled “Advances in Hybrid Biomaterials” is to present a comprehensive overview of new developments in the field. It is intended to highlight recent advances in (i) controlled synthesis and characterization of hybrid biomaterials, including new conjugation strategies, supramolecular assemblies and environmental responsive properties and (ii) the applications of biohybrids materials in biomedical field (drug delivery/targeting, diagnostics, etc.), colloid science, materials science, and so on. Original research papers, brief communication reports, as well as review articles, are all welcome.

Please feel free to disseminate this announcement to any colleagues who might be interested. I would appreciate all contributors who will aid in the success of this Special Issue.

Prof. Yuzhou Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • bioconjugation
  • biohybrids
  • self-assembly
  • protein
  • DNA
  • peptide
  • biopolymer
  • nanomedicine
  • hydrogel

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1973 KiB  
Communication
Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability
by Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu and Yuzhou Wu
Materials 2019, 12(6), 949; https://doi.org/10.3390/ma12060949 - 21 Mar 2019
Cited by 25 | Viewed by 4897
Abstract
DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under [...] Read more.
DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Graphical abstract

19 pages, 4234 KiB  
Article
Preparation and Characterization of Poly(δ-Valerolactone)/TiO2 Nanohybrid Material with Pores Interconnected for Potential Use in Tissue Engineering
by Waseem Sharaf Saeed, Abdel-Basit Al-Odayni, Ali Alrahlah, Abdulaziz Ali Alghamdi and Taieb Aouak
Materials 2019, 12(3), 528; https://doi.org/10.3390/ma12030528 - 10 Feb 2019
Cited by 10 | Viewed by 5277
Abstract
Titanium dioxide/poly(δ-valerolactone) (TiO2/Pδ-VL) nanohybrid material containing interconnected pores with sizes in the range 80–150 μm were prepared by the solvent casting and polymer melting routes, and the dispersion of the TiO2 nanofiller in the Pδ-VL matrix and its adhesion were [...] Read more.
Titanium dioxide/poly(δ-valerolactone) (TiO2/Pδ-VL) nanohybrid material containing interconnected pores with sizes in the range 80–150 μm were prepared by the solvent casting and polymer melting routes, and the dispersion of the TiO2 nanofiller in the Pδ-VL matrix and its adhesion were characterized by X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. A significant depression in the glass transition temperature (Tg) and melting temperature (Tm) values were revealed for the polymer nanocomposites prepared by the solvent casting technique. For the potential application of the prepared materials in the biomedical domain, complementary analyses were performed to examine the dynamic mechanical properties, and cell adhesion (using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay), and the results obtained for the samples prepared by the two methods were compared. Interconnected pores were successively produced in the new material by employing naphthalene microparticles as a porogen for the first time, and the results obtained were very promising. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Graphical abstract

13 pages, 3460 KiB  
Article
Synthesis and Preparation of Chitosan/Clay Microspheres: Effect of Process Parameters and Clay Type
by Bárbara Fernanda F. dos Santos, Matheus Aleixo Maciel, Albaniza A. Tavares, Clarissa Q. B. de Araújo Fernandes, Wladymyr Jefferson B. de Sousa, Marcus Vinícius Lia Fook, Itamara Farias Leite and Suédina Maria De Lima Silva
Materials 2018, 11(12), 2523; https://doi.org/10.3390/ma11122523 - 12 Dec 2018
Cited by 14 | Viewed by 4059
Abstract
This work aimed to prepare chitosan/clay microspheres, by the precipitation method, for use in drug carrier systems. The influence of the process parameters, particularly two airflows of the drag system (2.5 and 10 L·min−1) on the microspheres physical dimensions and properties, [...] Read more.
This work aimed to prepare chitosan/clay microspheres, by the precipitation method, for use in drug carrier systems. The influence of the process parameters, particularly two airflows of the drag system (2.5 and 10 L·min−1) on the microspheres physical dimensions and properties, such as microstructure, degree of swelling and porosity were evaluated. The samples were characterized by optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). Water absorption and porosity tests were also performed. The results showed that the process parameters affected the size of the microspheres. The diameter, volume and surface area of the chitosan/clay microspheres decreased when they were prepared with the higher airflow of the drag system. The microspheres presented a porous microstructure, being the pore size, percentage of porosity and degree of swelling affected not only by the process parameters but also by the type of clay. Hybrids (chitosan/clay) with intercalated morphology were obtained and the hybrid prepared with montmorillonite clay at higher airflows of the drag system presented the greatest interlayer spacing and a more disordered morphology. Thus, it is certain that the chitosan/clay nanocomposite microspheres prepared with montmorillonite (CL clay) at higher airflows of the drag system can have good drug-controlled release properties. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Figure 1

17 pages, 2707 KiB  
Article
Mesoporous Silica Nanoparticles for Dual-Mode Chemo-Sonodynamic Therapy by Low-Energy Ultrasound
by Jingjing Wang, Yajing Jiao and Yiran Shao
Materials 2018, 11(10), 2041; https://doi.org/10.3390/ma11102041 - 19 Oct 2018
Cited by 36 | Viewed by 5327
Abstract
Low-energy ultrasound (LEUS), exhibiting obvious advantages as a safe therapeutic strategy, would be promising for cancer therapy. We had synthesized a LEUS-responsive targeted drug delivery system based on functional mesoporous silica nanoparticle for cancer therapy. Paclitaxel (PTX) was loaded in mesoporous silica nanoparticles [...] Read more.
Low-energy ultrasound (LEUS), exhibiting obvious advantages as a safe therapeutic strategy, would be promising for cancer therapy. We had synthesized a LEUS-responsive targeted drug delivery system based on functional mesoporous silica nanoparticle for cancer therapy. Paclitaxel (PTX) was loaded in mesoporous silica nanoparticles with a hydrophobic internal channel, and folic acid (FA) functionalized β-Cyclodextrin (β-CD) was capped on the surface of the nanoparticles (DESN), which acted as a cancer-targeting moiety and solubilizer. The existence of a hydrophobic internal channel in the DESN was beneficial to the storage of hydrophobic PTX, along with the enhancement of the cavitation effect produced by mild low-energy ultrasound (LEUS, ≤1.0 W/cm2, 1 MHz). The DESN showed significantly enhanced cavitation effect, selective targeting, and achieved a rapid drug release under mild LEUS. To investigate the in vivo antitumor efficacy of the DESN upon LEUS irradiation, we established a 4T1 mammary tumor model. The DESN were confirmed to be of great biodegradability/biocompatibility. The tumor growth was significantly inhibited when the mice were treated with DESN (10 mg/kg) + LEUS with the relative tumor volume reduced to 4.72 ± 0.70 compared with the control group (V/V0 = 17.12 ± 2.75). The DESN with LEUS represented excellent inhibiting effect on tumor cell in vivo. This work demonstrated that DESN mediating dual mode chemo-sonodynamic therapy could be triggered by extracorporeal remote control, may suggest a promising clinical application in cancer therapy. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Graphical abstract

12 pages, 2444 KiB  
Article
Preparation and Enrichment Properties of Magnetic Dodecyl Chitosan/Silica Composite for Emerging Bisphenol Contaminants
by Jingrong Hu, Wangwei Liu, Huiling Liu, Lamei Wu and Huijuan Zhang
Materials 2018, 11(10), 1881; https://doi.org/10.3390/ma11101881 - 2 Oct 2018
Cited by 12 | Viewed by 3181
Abstract
Magnetic dodecyl chitosan/silica composite was synthesized and characterized for the enrichment of emerging bisphenol contaminants. The result demonstrated that bispehnol A, bisphenol AF, bisphenol F, and bisphenol S can be efficiently extracted via the resulting composite from aqueous solution. The adsorption rate of [...] Read more.
Magnetic dodecyl chitosan/silica composite was synthesized and characterized for the enrichment of emerging bisphenol contaminants. The result demonstrated that bispehnol A, bisphenol AF, bisphenol F, and bisphenol S can be efficiently extracted via the resulting composite from aqueous solution. The adsorption rate of four investigated bisphenols on the resulting composite was achieved in the range of 87–99% within 15 min. Bispehnol A was taken as a representative adsorbate to investigate the adsorption studies in detail. The hydrophobic interaction was proposed as the principal mechanism for the adsorption of BPs. The satisfactory reusability of the resulting composite can be quickly achieved by magnetic separation technologies. Magnetic dodecyl chitosan/silica composite has a potential to be applied as a type of efficient and easily recyclable sorbent for the removal of trace organic pollutants from aqueous sample. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Graphical abstract

11 pages, 2179 KiB  
Article
Biocompatible/Biodegradable Electrowetting on Dielectric Microfluidic Chips with Fluorinated CTA/PLGA
by Kaidi Zhang, Lei Chao and Jia Zhou
Materials 2018, 11(8), 1332; https://doi.org/10.3390/ma11081332 - 1 Aug 2018
Cited by 7 | Viewed by 3688
Abstract
One of the major hurdles in the development of biocompatible/biodegradable EWOD (Electrowetting-on-dielectric) devices is the biocompatibility of the dielectric and hydrophobic layers. In this study, we address this problem by using reactive ion etching (RIE) to prepare a super-hydrophobic film combining fluorinated cellulose [...] Read more.
One of the major hurdles in the development of biocompatible/biodegradable EWOD (Electrowetting-on-dielectric) devices is the biocompatibility of the dielectric and hydrophobic layers. In this study, we address this problem by using reactive ion etching (RIE) to prepare a super-hydrophobic film combining fluorinated cellulose triacetate (CTA) and poly (lactic-co-glycolic acid) (PLGA). The contact angle (CA) of water droplets on the proposed material is about 160°. X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) characterizations indicate that a slight increase in the surface roughness and the formation of CFx (C-F or CF2) bonds are responsible for the super-hydrophobic nature of the film. Alternating Current (AC) static electrowetting and droplet transportation experiments evidence that contact angle hysteresis and contact line pinning are greatly reduced by impregnating the CTA/PLGA film with silicon oil. Therefore, this improved film could provide a biocompatible alternative to the typical Teflon® or Cytop® films as a dielectric and hydrophobic layer. Full article
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop