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Materials 2019, 12(3), 528; https://doi.org/10.3390/ma12030528

Preparation and Characterization of Poly(δ-Valerolactone)/TiO2 Nanohybrid Material with Pores Interconnected for Potential Use in Tissue Engineering

1
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
2
Restorative Dental Sciences Department, Engineer Abdullah Bugshan research chair for Dental and Oral Rehabilitation College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Received: 27 December 2018 / Revised: 24 January 2019 / Accepted: 6 February 2019 / Published: 10 February 2019
(This article belongs to the Special Issue Advances in Hybrid Biomaterials)
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Abstract

Titanium dioxide/poly(δ-valerolactone) (TiO2/Pδ-VL) nanohybrid material containing interconnected pores with sizes in the range 80–150 μm were prepared by the solvent casting and polymer melting routes, and the dispersion of the TiO2 nanofiller in the Pδ-VL matrix and its adhesion were characterized by X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. A significant depression in the glass transition temperature (Tg) and melting temperature (Tm) values were revealed for the polymer nanocomposites prepared by the solvent casting technique. For the potential application of the prepared materials in the biomedical domain, complementary analyses were performed to examine the dynamic mechanical properties, and cell adhesion (using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay), and the results obtained for the samples prepared by the two methods were compared. Interconnected pores were successively produced in the new material by employing naphthalene microparticles as a porogen for the first time, and the results obtained were very promising. View Full-Text
Keywords: poly(δ-valerolactone)/titanium oxide nanocomposite; cell adhesion; pore connection; Tissue Engineering; mechanical properties poly(δ-valerolactone)/titanium oxide nanocomposite; cell adhesion; pore connection; Tissue Engineering; mechanical properties
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Saeed, W.S.; Al-Odayni, A.-B.; Alrahlah, A.; Alghamdi, A.A.; Aouak, T. Preparation and Characterization of Poly(δ-Valerolactone)/TiO2 Nanohybrid Material with Pores Interconnected for Potential Use in Tissue Engineering. Materials 2019, 12, 528.

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