Special Issue "Titania-Based Materials for Medical Applications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 15 September 2020.

Special Issue Editors

Assist. Prof. Piotr Piszczek
E-Mail Website
Guest Editor
Nicolaus Copernicus University, Torun, Poland
Interests: nanotechnologies; titanium and titania-based biomaterial; coordination compounds; structural studies and spectral characterization; medical applications
Dr. Aleksandra Radtke
E-Mail Website
Guest Editor
Nicolaus Copernicus University, Torun, Poland
Interests: titania-based materials; photocatalytic activity; modern implants; surface nanoarchitecture; bioactivity of nanomaterials

Special Issue Information

Dear Colleagues,

Intense works related to searching for new biomaterials and improvements of currently used ones are the response to the modern medicine demand for materials with new physicochemical and mechanical properties as well as with appropriate bioactivity. Such materials can be used in designing and construction of devices for various fields of modern medicine. Titania based-materials, which in addition to their beneficial mechanical properties are characterized by high biocompatibility, are an important group of biomaterials. These types of materials can be used to modify titanium or titanium alloys medical devices surface, e.g., implants used in orthopedic, dentistry, maxilla-facial, and spine surgery. The preparation of ceramic titanium materials with high chemical purity, characterized by specific physical and mechanical properties, is an interesting issue. The strictly defined nano- or microarchitecture of these materials allows their enrichment in anti-inflammatory agents, which can be gradually released, e.g., after a surgical procedure. It is also interesting to note that titania-based materials, due to their properties—surface morphology, structure, and reactivity—can affect the human body in different ways. Knowledge of these materials, their properties, and their synergistic effects is very important for optimal applications of these materials in various fields of medicine.

In spite of intensive investigations related to titania-based materials, studies on them are still an attractive topic. Therefore, we would like this Special Issue to become a place to present research results, exchange experiences, as well as for further cooperation on their use in various biomedical applications.

Your contributions are welcome.

Assist. Prof. Piotr Piszczek
Dr. Aleksandra Radtke
Guest Editors

Manuscript Submission Information

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Keywords

  • titania-based materials
  • structure
  • physicochemical and mechanical properties
  • bioactvity
  • medical applications

Published Papers (1 paper)

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Research

Open AccessArticle
In Vitro Studies on Nanoporous, Nanotubular and Nanosponge-Like Titania Coatings, with the Use of Adipose-Derived Stem Cells
Materials 2020, 13(7), 1574; https://doi.org/10.3390/ma13071574 (registering DOI) - 29 Mar 2020
Abstract
In vitro biological research on a group of amorphous titania coatings of different nanoarchitectures (nanoporous, nanotubular, and nanosponge-like) produced on the surface of Ti6Al4V alloy samples have been carried out, aimed at assessing their ability to interact with adipose-derived mesenchymal stem cells (ADSCs) [...] Read more.
In vitro biological research on a group of amorphous titania coatings of different nanoarchitectures (nanoporous, nanotubular, and nanosponge-like) produced on the surface of Ti6Al4V alloy samples have been carried out, aimed at assessing their ability to interact with adipose-derived mesenchymal stem cells (ADSCs) and affect their activity. The attention has been drawn to the influence of surface coating architecture and its physicochemical properties on the ADSCs proliferation. Moreover, in vitro co-cultures: (1) fibroblasts cell line L929/ADSCs and (2) osteoblasts cell line MG-63/ADSCs on nanoporous, nanotubular and nanosponge-like TiO2 coatings have been studied. This allowed for evaluating the impact of the surface properties, especially roughness and wettability, on the creation of the beneficial microenvironment for co-cultures and/or enhancing differentiation potential of stem cells. Obtained results showed that the nanoporous surface is favorable for ADSCs, has great biointegrative properties, and supports the growth of co-cultures with MG-63 osteoblasts and L929 fibroblasts. Additionally, the number of osteoblasts seeded and cultured with ADSCs on TNT5 surface raised after 72-h culture almost twice when compared with the unmodified scaffold and by 30% when compared with MG-63 cells growing alone. The alkaline phosphatase activity of MG-63 osteoblasts co-cultured with ADSCs increased, that indirectly confirmed our assumptions that TNT-modified scaffolds create the osteogenic niche and enhance osteogenic potential of ADSCs. Full article
(This article belongs to the Special Issue Titania-Based Materials for Medical Applications)
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