Special Issue "Surface Properties of Nanoparticles and Their Applications in Biomedicine"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editor

Prof. Jae-Seung Lee
Guest Editor
Department of Materials Science and Engineering, College of Engineering, Korea University, Seoul, 02841, Republic of Korea
Interests: synthetic control of noble metal nanostructures; surface-functionalization of nanomaterials for advanced chemical properties; nanomaterial-based photothermal therapy and drug delivery, colorimetric sensing of biomolecular targets

Special Issue Information

Dear Colleagues,

Controlling the surface properties of nanoparticles has been one of the most promising developments in nanomaterials science. Although the intrinsic properties of bare nanoparticle surfaces depend on the elemental composition, size, and shape of the particles, surface functionalization dramatically changes their overall chemical and physical properties because of the high surface-to-volume ratio. From the point of view of interfacial phenomena, the chemical interactions of the particles with their local environment, such as ions, pH, and hydrophilicity/hydrophobicity of solvent molecules, can be fine-tuned for specific biomedical purposes, such as biochemical sensing and imaging, drug delivery, photothermal therapy, and general bioanalytical applications, by an appropriate choice of surface ligands. The outstanding advantages of nanoparticles with functional surface properties over their molecular counterparts can be explored for various potential clinical applications.  

In this Special Issue, I invite researchers to submit original full papers, communications, and review articles on any of the abovementioned topics. I particularly welcome contributions dealing with recent advances in controlling the surface properties of nanoparticles for various biomedical and bioanalytical applications.

Authors can submit their manuscripts online at https://www.mdpi.com/journal/materials/. Please mention clearly in the cover letter that the manuscript is to be considered for publication in this specific Special Issue. All manuscripts will undergo a routine peer-review process, and accepted manuscripts will form part of the Special Issue .

Prof. Jae-Seung Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nanoparticle
  • Surface property
  • Functionalization
  • Surface modification
  • Biomedicine
  • Sensing
  • Imaging
  • Drug delivery
  • Photothermal therapy
  • Bioanalysis
  • Clinical application

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

(1) Title: Insights into Characterization Methods and Biomedical Applications of Nanoparticle-Protein Corona

Authors: Yan Li and Jae-Seung Lee

Type: Review
Affiliation: Department of Materials Science and Engineering, College of Engineering, Korea University, Seoul, 02841, Republic of Korea

Outline: Nanoparticles (NPs) expose to a biological milieu will strongly interact with proteins, which form “a corona” in the surface of NPs. Protein corona affects the NPs’ properties and gives a new biological identity to the particles in the biological environment. Characterization of the NP-protein corona has attracted enormous research attention owing to the crucial effect of NP-protein corona’s properties on its interaction with living systems as well as its applications. Analysis of the NP-protein corona without a well-thought-through approach will inevitably lead to misunderstanding and inappropriate applications of NPs. This Review introduces methods for characterization of NP-protein corona and its recent applications in biomedicine. Furthermore, it evaluates these characterization methods with comprehensive critical views, and provides future perspectives about applications of NP-protein corona.
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