Special Issue "Biomedical Application of Carbon Nanostructure Modifications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Carbon Materials".

Deadline for manuscript submissions: 20 August 2020.

Special Issue Editor

Prof. Olga E. Glukhova
E-Mail Website1 Website2
Guest Editor
1) Department of Physics, Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia
2) Institute for bionic technologies and engineering, I.M. Sechenov First Moscow State Medical University, bld. 2-4, Bolshaya Pirogovskaya street, Moscow, 119991, Russia
Interests: nanoelectronics; mechanics of nanostructures; molecular modeling of nanostructures and biosystems; quantum chemistry and molecular dynamics; carbon nanostructures (fullerenes, nanotubes, graphene, graphane); condensed matter physics; materials science – biomaterials; biophysics

Special Issue Information

Dear Colleagues,

Carbon nanostructures and their modifications have penetrated into all spheres of human activity, because at the end of the 20th century, they first radically changed electronics, giving rise to nanoelectronics, and then «cut a window» for new biomedical technologies. Carbon nanotube-based highly stretchable transparent conductive thin films are promising and are actively being introduced in the field of wearable electronics and biometric sensors, designed to save lives, diagnosing and preventing pathological processes in time. Laser-processed carbon nanotubes form branched 3D structures (carbon matrices), on the basis of which protein and polymer matrices are created. These new biocompatible composite nanomaterials are used for the proliferation of neuronal, cartilage, and bone cells, as well as in tissue engineering as implants with increased strength, as well as the basis of artificial muscles. Graphene and graphene oxide (GO) structures and their reduced forms are already being used for electrical identification of DNA, anticancer therapy, as functional drug delivery carriers, and bioimaging. New graphene/CNT-based composites allow not only manufacturing nanofilters, but also electrochemical biosensors as a means of express detection of toxins in the event of water pollution. The recently obtained convincing evidence of the nontoxicity of fullerenes and even their positive effect on human health opens new perspectives for their use in pharmacology and drug delivery. The great advantage of fullerenes over other allotropic carbon phases is their high capacity for functionalization. The discovery of new unique properties of carbon nanostructure modifications and the identification of the most optimal and effective nanomaterials based on graphene, carbon nanotubes, fullerenes, and other carbon nanostructures is a very important area that requires new ideas and new theoretical and technological searches and solutions.

This Special Issue highlights new ideas about the creation and use of carbon nanostructure-based nanomaterials for biomedical purposes. New technological solutions to improve the characteristics of existing and already used carbon nanomaterials are also being proposed. New approaches to the study of properties and the discovery of new unique features of carbon nanostructures from the standpoint of the expansion of their biomedical applications are considered.

I am pleased to invite you to submit a manuscript for this Special Issue. Full papers, reports, and reviews are welcome.

Prof. Olga E. Glukhova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible composite based on graphene and carbon nanotube
  • functionalized fullerenes
  • graphene modifications
  • biometric sensors
  • 3D carbon matrices
  • functional drug delivery carriers
  • wearable electronics

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. DNA sensors based on graphene-nanotube composite films and graphene films with vertically oriented carbon nanotubes

Dmitry S. Shmygin1, Michael M. Slepchenkov1, Alexander Yu. Gerasimenko2,3,

Dmitry V. Telyshev2,3 and Olga Glukhova1,2,*

1   Saratov State University, Astrakhanskaya street 83, 410012 Saratov, Russia

2   I.M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya street 2-4, 119991 Moscow, Russia

3   National Research University of Electronic Technology MIET, Shokin Square 1, 124498 Zelenograd, Moscow, Russia

*   Correspondence: [email protected]; Tel.:+7 8452 514562

 

The possibilities of using graphene-nanotube films and graphene films with vertically oriented carbon nanotubes as sensors for DNA macromolecules are investigated. A feature of graphene-nanotube films is a large active surface and topological features that determine the sites of DNA adsorption. The patterns of changes in electrical conductivity and current-voltage characteristics during DNA adsorption calculated by quantum methods allowed us to identify the most promising topological types of composite films. Comparative studies of composite films with zigzag and armchair graphene nanoribbons have shown that composite films are most preferred. A certain mutual arrangement of graphene sheets and carbon nanotubes in composite films allows us to achieve a relative change in the electrical conductivity by 100-200% during the deposition of DNA nucleotides.

 

2. The structure of nanocomposites based on protein media with single-walled carbon nanotubes depending on their type and concentration

Alexander Yu. Gerasimenko1,2,*, Olga Glukhova3,2

1   National Research University of Electronic Technology MIET, Shokin Square 1, 124498 Zelenograd, Moscow, Russia

2   I.M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya street 2-4, 119991 Moscow, Russia

3   Saratov State University, Astrakhanskaya street 83, 410012 Saratov, Russia

*   Correspondence: [email protected]; Tel.:+79267029778

 

Abstract: The structural features of nanocomposites obtained by laser evaporation of aqueous protein media (albumin, collagen) with two types of single-walled carbon nanotubes (SWCNTs) were studied. SWCNTs I were synthesized by electrophoresis and had a smaller diameter and length than SWCNTs II, which were synthesized by the gas-phase method. Nanocomposites were a multilayer structure consisting of layers and nanotubes in collagen and albumin matrices. Using Raman spectroscopy of nanocomposites, the nature of the nanotubes interaction (with different concentrations of 0.1 and 0.01 wt.%) with protein molecules was determined. The protein component in nanocomposites underwent denaturation. It can play the role of binding biocompatible material, which is the source of amino acids for biological tissues during implantation of nanocomposites into the body. It was found that nanocomposites made from SWCNTs I, which had smaller diameter and length, had more homogenous structure. With increasing concentration from 0.01 to 0.1 wt.%, there was an increase in micropores size from 45 to 85 microns and the porosity of the sample in general from 46 to 58 %. The ratio of open pores to the total composite volume for two types of SWCNTs I concentrations was 2 %. The presence of mesopores is shown in nanocomposites based on SWCNTs I. An increase in the concentration of nanotubes led to a decrease in the specific surface values and pore volume of the nanocomposite. The studied nanocomposites can be used as tissue engineering matrices for the restoration of bulk defects in biological tissues. Using molecular modeling, a nanocomposites model was constructed.

Keywords: nanocomposites, laser radiation, structure, carbon nanotubes, structuring, proteins, porosity, molecular dynamics, interaction energy

 

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