Special Issue "Bioactive Glasses 2019"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editor

Prof. Dr. Gigliola Lusvardi
E-Mail Website
Guest Editor
Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G.Campi 103, 41125 Modena, Italy
Interests: biomaterials; bioceramics; bioglasses; metallic nanoparticles; drug delivery systems; synthesis (traditional, sol-gel and sono-gel); functional biomaterials; surface functionalization; biosensors; characterization (x-ray diffraction, electron microscopy)
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Special Issue Information

Dear Colleagues,

Bioactive glasses are a group of surface-reactive, glass–ceramic biomaterials; bioactive glasses bond to tissues and are biocompatible. They have a wide range of applications due to their versatile properties, which can be properly designed depending on their composition. A significant improvement in the prevision of glass bioactivity derives from the opportunity to establish relationships between structure and properties by making a combined use of theoretical and experimental techniques. Consequently, bioactive glass science and technology continues to be at the forefront of providing innovative approaches to medicine. The focus of the “Bioactive glasses 2018” Special Issue is to provide and comprehend important topics: Synthesis, design, development and applications of bioglasses. Some interesting topics (among others, and not limited to) are: Bioderived bioglasses with functionalized nanostructures, encapsulation and adsorption of biomolecules in the surface of bioglasses and interactions with the host matrix, molecular dynamics simulation applied at the atomic level regarding the bulk and surface structures of the glasses. With immense pleasure, we invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are welcome.

Prof. Dr. Gigliola Lusvardi
Guest Editor

Manuscript Submission Information

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Keywords

  • bioactive glasses
  • materials science
  • bioactivity
  • metal nanoparticles
  • glass structure
  • surface functionalization
  • drug delivery systems

Published Papers (3 papers)

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Research

Open AccessArticle
P2O5-Free Cerium Containing Glasses: Bioactivity and Cytocompatibility Evaluation
Materials 2019, 12(19), 3267; https://doi.org/10.3390/ma12193267 - 08 Oct 2019
Abstract
(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain [...] Read more.
(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain 1.2, 3.6, and 5.3 mol% of CeO2. Bioactivity and cytotoxicity tests were carried out in simulated body fluid (SBF) solution and murine osteocyte (MLO-Y4) cell lines, respectively. Leaching of ions concentration in SBF was determined by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). The surface of the glasses were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. (3) Results: P2O5-free cerium doped glasses are proactive according to European directives. Cerium increases durability and retards, but does not inhibit, (Ca10(PO4)6(OH)2, HA) formation at higher cerium amounts (K3.6 and K5.3); however, cell proliferation increases with the amount of cerium especially evident for K5.3. (4) Conclusions: These results enforce the use of P2O5-free cerium doped bioactive glasses as a new class of biomaterials. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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Open AccessArticle
Control of Dopant Distribution in Yttrium-Doped Bioactive Glass for Selective Internal Radiotherapy Applications Using Spray Pyrolysis
Materials 2019, 12(6), 986; https://doi.org/10.3390/ma12060986 - 25 Mar 2019
Abstract
In this study, we demonstrate the fabrication of Y-doped bioactive glass (BG), which is proposed as a potential material for selective internal radiotherapy applications. Owing to its superior bioactivity and biodegradability, it overcomes the problem of yttrium aluminosilicate spheres that remain in the [...] Read more.
In this study, we demonstrate the fabrication of Y-doped bioactive glass (BG), which is proposed as a potential material for selective internal radiotherapy applications. Owing to its superior bioactivity and biodegradability, it overcomes the problem of yttrium aluminosilicate spheres that remain in the host body for a long duration after treatment. The preparation of Y-doped BG powders were carried out using a spray pyrolysis method. By using two different yttrium sources, we examine the change of the local distribution of yttrium concentration. In addition, characterizations of phase information, particle morphologies, surface areas, and bioactivity were also performed. The results show that both Y-doped BG powders are bioactive and the local Y distribution can be controlled. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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Open AccessFeature PaperArticle
Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5
Materials 2019, 12(4), 594; https://doi.org/10.3390/ma12040594 - 16 Feb 2019
Cited by 2
Abstract
The cytocompatibility of potential bioactive cerium-containing (Ce3+/Ce4+) glasses is here investigated by preparing three different glasses with increasing amount of doping CeO2 (1.2, 3.6 and 5.3 mol% of CeO2, called BG_1.2, BG_3.6 and BG_5.3, respectively) based [...] Read more.
The cytocompatibility of potential bioactive cerium-containing (Ce3+/Ce4+) glasses is here investigated by preparing three different glasses with increasing amount of doping CeO2 (1.2, 3.6 and 5.3 mol% of CeO2, called BG_1.2, BG_3.6 and BG_5.3, respectively) based on 45S5 Bioglass® (called BG). These materials were characterized by Environmental Scanning Electron Microscopy (ESEM) and infrared spectroscopy (FTIR) after performing bioactivity tests in Dulbecco’s Modified Eagle Medium (DMEM) solution, and the ions released in solution were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Optical Emission Spectrometry (ICP-OES). The data obtained clearly show that the glass surfaces of BG, BG_1.2 and BG_3.6 were covered by hydroxyapatite (HA), while BG_5.3 favored the formation of a cerium phosphate crystal phase. The cytotoxicity tests were performed using both murine long bone osteocyte-like (MLO-Y4) and mouse embryonic fibroblast (NIH/3T3) cell lines. The cerium-containing bioactive glasses show an increment in cell viability with respect to BG, and at long times, no cell aggregation and deformation were observed. The proliferation of NIH/3T3 cells increased with the cerium content in the glasses; in particular, BG_3.6 and BG_5.3 showed a higher proliferation of cells than the negative control. These results highlight and enforce the proposal of cerium-doped bioactive glasses as a new class of biomaterials for hard-tissue applications. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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