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Open AccessArticle

P2O5-Free Cerium Containing Glasses: Bioactivity and Cytocompatibility Evaluation

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Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41125 Modena, Italy
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Lab. Biomaterials, Department of Medical and Surgical Sciences of Children & Adults, University of Modena and Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(19), 3267; https://doi.org/10.3390/ma12193267
Received: 31 July 2019 / Revised: 12 September 2019 / Accepted: 5 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Bioactive Glasses 2019)
(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain 1.2, 3.6, and 5.3 mol% of CeO2. Bioactivity and cytotoxicity tests were carried out in simulated body fluid (SBF) solution and murine osteocyte (MLO-Y4) cell lines, respectively. Leaching of ions concentration in SBF was determined by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). The surface of the glasses were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. (3) Results: P2O5-free cerium doped glasses are proactive according to European directives. Cerium increases durability and retards, but does not inhibit, (Ca10(PO4)6(OH)2, HA) formation at higher cerium amounts (K3.6 and K5.3); however, cell proliferation increases with the amount of cerium especially evident for K5.3. (4) Conclusions: These results enforce the use of P2O5-free cerium doped bioactive glasses as a new class of biomaterials. View Full-Text
Keywords: bioactive glasses; cerium; bioactivity; cytocompatibility; cell proliferation bioactive glasses; cerium; bioactivity; cytocompatibility; cell proliferation
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MDPI and ACS Style

Lusvardi, G.; Sgarbi Stabellini, F.; Salvatori, R. P2O5-Free Cerium Containing Glasses: Bioactivity and Cytocompatibility Evaluation. Materials 2019, 12, 3267.

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