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Open AccessFeature PaperArticle

Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5

1
Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Modena e Reggio Emilia, via G. Campi 103, 41125 Modena, Italy
2
Laboratorio dei Biomateriali, Dipartimento di Scienze Mediche Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Via G. Campi 213/A, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(4), 594; https://doi.org/10.3390/ma12040594
Received: 22 December 2018 / Revised: 9 February 2019 / Accepted: 12 February 2019 / Published: 16 February 2019
(This article belongs to the Special Issue Bioactive Glasses 2019)
The cytocompatibility of potential bioactive cerium-containing (Ce3+/Ce4+) glasses is here investigated by preparing three different glasses with increasing amount of doping CeO2 (1.2, 3.6 and 5.3 mol% of CeO2, called BG_1.2, BG_3.6 and BG_5.3, respectively) based on 45S5 Bioglass® (called BG). These materials were characterized by Environmental Scanning Electron Microscopy (ESEM) and infrared spectroscopy (FTIR) after performing bioactivity tests in Dulbecco’s Modified Eagle Medium (DMEM) solution, and the ions released in solution were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Optical Emission Spectrometry (ICP-OES). The data obtained clearly show that the glass surfaces of BG, BG_1.2 and BG_3.6 were covered by hydroxyapatite (HA), while BG_5.3 favored the formation of a cerium phosphate crystal phase. The cytotoxicity tests were performed using both murine long bone osteocyte-like (MLO-Y4) and mouse embryonic fibroblast (NIH/3T3) cell lines. The cerium-containing bioactive glasses show an increment in cell viability with respect to BG, and at long times, no cell aggregation and deformation were observed. The proliferation of NIH/3T3 cells increased with the cerium content in the glasses; in particular, BG_3.6 and BG_5.3 showed a higher proliferation of cells than the negative control. These results highlight and enforce the proposal of cerium-doped bioactive glasses as a new class of biomaterials for hard-tissue applications. View Full-Text
Keywords: bioactive glasses; cerium oxide; hydroxyapatite; cytocompatibility; cell viability; cell proliferation bioactive glasses; cerium oxide; hydroxyapatite; cytocompatibility; cell viability; cell proliferation
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MDPI and ACS Style

Malavasi, G.; Salvatori, R.; Zambon, A.; Lusvardi, G.; Rigamonti, L.; Chiarini, L.; Anesi, A. Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5. Materials 2019, 12, 594. https://doi.org/10.3390/ma12040594

AMA Style

Malavasi G, Salvatori R, Zambon A, Lusvardi G, Rigamonti L, Chiarini L, Anesi A. Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5. Materials. 2019; 12(4):594. https://doi.org/10.3390/ma12040594

Chicago/Turabian Style

Malavasi, Gianluca; Salvatori, Roberta; Zambon, Alfonso; Lusvardi, Gigliola; Rigamonti, Luca; Chiarini, Luigi; Anesi, Alexandre. 2019. "Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5" Materials 12, no. 4: 594. https://doi.org/10.3390/ma12040594

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