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Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis...
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Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 April 2025) | Viewed by 8092

Special Issue Editors

Dr. Tanmay Kulkarni

E-Mail Website
Guest Editor
Assistant Professor, Department of Biochemistry and Molecular Biology at Mayo Clinic Florida, Jacksonville, FL, USA
Interests: biophysics; nanomechanics of nanoparticles; cell–nanoparticle nanomechanical interactions; cell and tissue mechanics in the presence of anticancer drugs; influence of drug delivery on extracellular matrix remodeling
Dr. Krishnendu Pal

E-Mail Website
Guest Editor
Assistant Professor, Department of Biochemistry and Molecular Biology at Mayo Clinic Florida, Jacksonville, FL, USA
Interests: renal cancer; lung cancer; drug resistance; drug delivery systems; liposomes; nanomaterials; nanomedicine; xenograft models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains one of the most difficult pathologies to treat owing to dense stroma, late detection, and resistance to drugs. Several individual treatment modalities and/or combination therapies are proving to be promising, yet there is still no effective therapy exist due to the dynamic nature of this disease. Novel therapeutic interventions for cancer treatments are the need of the hour. The drawbacks of conventional drug delivery include nonspecific targeting, toxicity, reduced efficacy, and a low therapeutic index. Moreover, the lack of real-time prognosis often results in under- or overtreatment, ultimately leading to drug resistance or toxicity, respectively. This Special Issue aims to encourage the design and testing of advanced biomaterials for early detection, drug delivery, treatment, and prognosis that will overcome the limitations of conventional drug therapy. While the focus is on the synthesis and therapeutic/theranostic evaluation of these advanced biomaterials, this multidisciplinary field is extended to incorporate nano- and macroscale biophysical attributes of advanced biomaterials and their interaction with biological components both in vitro and in vivo. Manuscripts with a scientifically sound approach backed with mechanistic insights into therapeutic implications/translational effects are highly encouraged. Review articles covering the present state-of-the-art technologies are also welcomed.

Dr. Tanmay Kulkarni
Dr. Krishnendu Pal
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • nanomaterials
  • advanced microscopy techniques
  • biophysical attributes
  • drug delivery
  • drug resistance
  • combination therapy
  • theranostics

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Published Papers (5 papers)

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Research

15 pages, 2196 KiB  
Article
Microfluidic Fabrication of Oleosin-Coated Liposomes as Anticancer Drug Carriers with Enhanced Sustained Drug Release
by Yoseph Seo, Yeeun Woo, Byeolnim Oh, Daehyeon Yoo, Hyeok Ki Kwon, Chulhwan Park, Hyeon-Yeol Cho, Hyun Soo Kim and Taek Lee
Materials 2024, 17(22), 5550; https://doi.org/10.3390/ma17225550 - 13 Nov 2024
Cited by 2 | Viewed by 1222
Abstract
Microfluid-derived liposomes (M-Lipo) exhibit great potential as drug and functional substance carriers in pharmaceutical and food science. However, the low liposome membrane stability, attributed to the liquid core, limits their application range. Oleosin, a natural surfactant protein, can improve the stability of the [...] Read more.
Microfluid-derived liposomes (M-Lipo) exhibit great potential as drug and functional substance carriers in pharmaceutical and food science. However, the low liposome membrane stability, attributed to the liquid core, limits their application range. Oleosin, a natural surfactant protein, can improve the stability of the lipid nanoparticle membrane against various environmental stresses, such as heat, drying, and pH change; in addition, it can enable sustained drug release. Here, we proposed the fabrication of oleosin-coated M-Lipo (OM-Lipo) through self-assembly on a microfluidic chip and the evaluation of its anticancer drug (carmustine) delivery efficiency. Nanoparticle characterization revealed that the oleosin coating slightly lowered the membrane potential of M-Lipo and greatly improved their dispersibility. Additionally, the in vitro drug release profile showed that the oleosin coating improved the sustained release of the hydrophobic drug from the phospholipid bilayer in body temperature. Our results suggest that OM-Lipo has sufficient potential in various fields, based on its easy production, excellent stability, and biocompatibility. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer)
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19 pages, 4286 KiB  
Article
Biomaterials in Cancer Therapy: Investigating the Interaction between Kaempferol and Zinc Ions through Computational, Spectroscopic and Biological Analyses
by Aleksandra Golonko, Adam Jan Olichwier, Adam Paszko, Renata Świsłocka, Łukasz Szczerbiński and Włodzimierz Lewandowski
Materials 2024, 17(11), 2526; https://doi.org/10.3390/ma17112526 - 24 May 2024
Viewed by 1366
Abstract
A complex of the natural flavonoid kaempferol with zinc (Kam-Zn) was synthesized, and its physicochemical properties were investigated using spectroscopic methods such as Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible (UV-Vis) spectroscopy and theoretical chemistry. Biological studies were conducted to evaluate the cytotoxic and [...] Read more.
A complex of the natural flavonoid kaempferol with zinc (Kam-Zn) was synthesized, and its physicochemical properties were investigated using spectroscopic methods such as Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible (UV-Vis) spectroscopy and theoretical chemistry. Biological studies were conducted to evaluate the cytotoxic and antiproliferative effects of these complexes on MCF-7 breast cancer cells. Treatment with Kam 100 µM (84.86 ± 7.79%; 64.37 ± 8.24%) and Kam-Zn 100 µM (91.87 ± 3.80%; 87.04 ± 13.0%) showed no significant difference in proliferation between 16 h and 32 h, with the gap width remaining stable. Both Kam-Zn 100 μM and 200 μM demonstrated effective antiproliferative and cytotoxic activity, significantly decreasing cell viability and causing cell death and morphology changes. Antioxidant assays revealed that Kam (IC50 = 5.63 ± 0.06) exhibited higher antioxidant potential compared to Kam-Zn (IC50 = 6.80 ± 0.075), suggesting that zinc coordination impacts the flavonoid’s radical scavenging activity by the coordination of metal ion to hydroxyl groups. Computational studies revealed significant modifications in the electronic structure and properties of Kam upon forming 1:1 complexes with Zn2+ ions. Spectroscopy analyses confirmed structural changes, highlighting shifts in absorption peaks and alterations in functional group vibrations indicative of metal–ligand interactions. FT-IR and UV-Vis spectra analysis suggested that Zn coordinates with the 3-OH and 4C=O groups of ligand. These findings suggest that the Kam-Zn complex exhibits interesting antiproliferative, cytotoxic and modified antioxidant effects on MCF-7 cells, providing valuable insights into their structural and anticancer properties. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer)
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15 pages, 11140 KiB  
Article
Gelatin–Zinc Carrier as a New Method of Targeted and Controlled Release of Risedronate
by Jakub Reczkowski, Maria Długosz, Maria Ratajczak, Adam Voelkel and Mariusz Sandomierski
Materials 2024, 17(11), 2473; https://doi.org/10.3390/ma17112473 - 21 May 2024
Viewed by 1381
Abstract
The essence of drug delivery is to use an appropriate carrier that delivers the active substance to the appropriate pathogenic site at a specific time. This study aims to develop a novel drug carrier characterized by the controlled and targeted release of risedronate [...] Read more.
The essence of drug delivery is to use an appropriate carrier that delivers the active substance to the appropriate pathogenic site at a specific time. This study aims to develop a novel drug carrier characterized by the controlled and targeted release of risedronate (RSD). The search for new routes to deliver RSD is important because oral delivery has many disadvantages. The carrier proposed in this work is composed of gelatin, polyphosphates, and zinc. The zinc contained in the carrier is responsible for coordinating the drug. The resulting material releases RSD in a controlled manner. The rate of delivery of the substance to the body depends on the pH of the environment. This study investigated the delivery of RSD in a neutral environment, where the process exhibited a prolonged and consistent release rate. This process has also been studied in an acidic environment, which accelerates the release of the drug. Mixed-environment studies were also conducted. Initially, the drug was released in a neutral environment, and then the conditions rapidly changed to acidic. In this case, the carrier demonstrated high stability and controlled release, adapting the rate of drug release to the prevailing environmental conditions. The presented results indicate the great potential of the new gelatin-based carrier in the delivery of risedronate. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer)
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20 pages, 9311 KiB  
Article
Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
by Ana Nicolao-Gómez, Enrique Martínez-Campos, Lara Moreno, Juan Rodríguez-Hernández and Endzhe Matykina
Materials 2023, 16(24), 7688; https://doi.org/10.3390/ma16247688 - 18 Dec 2023
Cited by 5 | Viewed by 1966
Abstract
A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell [...] Read more.
A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell adhesion. The inner, ceramic layer formed by plasma electrolytic oxidation (PEO) has been enriched in bioactive elements (Ca, P, Si). The intermediate PCL layer sealed the defect in the PEO layer and the outer microporous PCL layer loaded with the appropriate active molecule, thus providing drug-eluting capacity. Morphological, chemical, and biological characterizations of the manufactured coatings loaded with ciprofloxacin (CIP) and paracetamol (PAR) have been carried out. In vitro assays with cell lines relevant for cardiovascular implants and bone prosthesis (endothelial cells and premyoblasts) showed that the drug-loaded coating allows for cell proliferation and viability. The study of CIP and PAR cytotoxicity and release rate indicated that the porous PCL layer does not release concentrations detrimental to the cells. However, complete system assays revealed that corrosion behavior and increase of the pH negatively affects cell viability. H2 evolution during corrosion of Mg alloy substrate generates blisters in PCL layer that accelerate the corrosion locally in crevice microenvironment. A detailed mechanism of the system degradation is disclosed. The accelerated degradation of the developed system may present interest for its further adaptation to new cancer therapy strategies. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer)
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12 pages, 2954 KiB  
Article
Rational Design of a Small Molecular Near-Infrared Fluorophore for Improved In Vivo Fluorescence Imaging
by Gayoung Jo, Yoonbin Park, Min Ho Park and Hoon Hyun
Materials 2023, 16(22), 7227; https://doi.org/10.3390/ma16227227 - 18 Nov 2023
Cited by 1 | Viewed by 1485
Abstract
The near-infrared (NIR) fluorescence imaging modality has great potential for application in biomedical imaging research owing to its unique characteristics, such as low tissue autofluorescence and noninvasive visualization with high spatial resolution. Although a variety of NIR fluorophores are continuously reported, the commercially [...] Read more.
The near-infrared (NIR) fluorescence imaging modality has great potential for application in biomedical imaging research owing to its unique characteristics, such as low tissue autofluorescence and noninvasive visualization with high spatial resolution. Although a variety of NIR fluorophores are continuously reported, the commercially available NIR fluorophores are still limited, owing to complex synthetic processes and poor physicochemical properties. To address this issue, a small molecular NIR fluorophore (SMF800) was designed and developed in the present work to improve in vivo target-specific fluorescence imaging. After conjugation with pamidronate (PAM) and bovine serum albumin (BSA), the SMF800 conjugates exhibited successful in vivo targeting in bone and tumor tissues with low background uptake, respectively. The improved in vivo performance of the SMF800 conjugate demonstrated that the small molecular NIR fluorophore SMF800 can be widely used in a much broader range of imaging applications. The structure of SMF800, which was developed by considering two important physicochemical properties, water solubility and conjugatability, is first introduced. Therefore, this work suggests a simple and rational approach to design small, hydrophilic, and conjugatable NIR fluorophores for targeted bioimaging. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer)
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