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Materials
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Drug Delivery: Recent Developments and Future Prospects (Volume II)
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Drug Delivery: Recent Developments and Future Prospects (Volume II)

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 1523

Special Issue Editors

Dr. Marilena Vlachou

E-Mail Website1 Website2
Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug carriers; drug delivery; biopolymers; nanotechnology; nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Angeliki Siamidi

E-Mail Website
Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug delivery; controlled release; modified release; statistical analysis; melatonin; tablet; formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The effectiveness of drugs is significantly related to their route of delivery. Thus, the development of efficient drug delivery systems (DDSs) is of paramount importance to better control the pharmacodynamic and pharmacokinetic profile of drugs. Other aspects, such as immunogenicity and toxicity, are also impacted by their delivery mechanism.

Currently, materials in the nanoscale range are employed to deliver drugs to specific targeted sites in a controlled manner. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources are currently subject to intense scrutiny, and the information regarding the trends and perspectives in the field of nanomedicine is very promising. However, these delivery vehicles are only a small selection of those that are currently available.

In this, the second volume of the Special Issue "Drug Delivery: Recent Developments and Future Prospects (Volume II)", we aim to enrich this particular field of drug delivery systems by inviting colleagues to contribute their research work on cutting-edge drug delivery carriers with promising perspectives.

Dr. Marilena Vlachou
Dr. Angeliki Siamidi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug carriers
  • drug delivery
  • biopolymers
  • nanotechnology
  • nanomaterials

Published Papers (1 paper)

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Research

20 pages, 1616 KiB  
Article
Development of Liposomal and Liquid Crystalline Lipidic Nanoparticles with Non-Ionic Surfactants for Quercetin Incorporation
by Ioannis Tsichlis, Athanasia-Paraskevi Manou, Vasiliki Manolopoulou, Konstantina Matskou, Maria Chountoulesi, Vasiliki Pletsa, Aristotelis Xenakis and Costas Demetzos
Materials 2023, 16(16), 5509; https://doi.org/10.3390/ma16165509 - 08 Aug 2023
Viewed by 1228
Abstract
The aim of the present study is the development, physicochemical characterization, and in vitro cytotoxicity evaluation of both empty and quercetin-loaded HSPC (hydrogenated soy phosphatidylcholine) liposomes, GMO (glyceryl monooleate) liquid crystalline nanoparticles, and PHYT (phytantriol) liquid crystalline nanoparticles. Specifically, HSPC phospholipids were mixed [...] Read more.
The aim of the present study is the development, physicochemical characterization, and in vitro cytotoxicity evaluation of both empty and quercetin-loaded HSPC (hydrogenated soy phosphatidylcholine) liposomes, GMO (glyceryl monooleate) liquid crystalline nanoparticles, and PHYT (phytantriol) liquid crystalline nanoparticles. Specifically, HSPC phospholipids were mixed with different non-ionic surfactant molecules (Tween 80 and/or Span 80) for liposomal formulations, whereas both GMO and PHYT lipids were mixed with Span 80 and Tween 80 as alternative stabilizers, as well as with Poloxamer P407 in different ratios for liquid crystalline formulations. Subsequently, their physicochemical properties, such as size, size distribution, and ζ-potential were assessed by the dynamic and electrophoretic light scattering (DLS/ELS) techniques in both aqueous and biological medium with serum proteins. The in vitro biological evaluation of the empty nanosystems was performed by using the MTT cell viability and proliferation assay. Finally, the entrapment efficiency of quercetin was calculated and the differences between the two different categories of lipidic nanoparticles were highlighted. According to the results, the incorporation of the non-ionic surfactants yields a successful stabilization and physicochemical stability of both liposomal and liquid crystalline nanoparticles. Moreover, in combination with an appropriate biosafety in vitro profile, increased encapsulation efficiency of quercetin was achieved. Overall, the addition of surfactants improved the nanosystem’s stealth properties. In conclusion, the results indicate that the physicochemical properties were strictly affected by the formulation parameters, such as the type of surfactant. Full article
(This article belongs to the Special Issue Drug Delivery: Recent Developments and Future Prospects (Volume II))
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