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Green Chemistry and Nanomaterials: Applications in Drug Delivery and Biomedical Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 January 2026) | Viewed by 2426

Special Issue Editor


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Guest Editor
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy
Interests: nanotechnology; liposomes; niosomes; transfersomes; aerogels; biomaterials, nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, medicine has faced a revolution due to the introduction of novel, advanced, and smart biomaterials for different applications: from controlled and targeted drug delivery to regenerative tissue engineering to theranostics. For this reason, both the scientific community and industry are working on this challenging research topic, with special focus on the types of processes involved.

For this Special Issue, we kindly invite authors to contribute their original research articles and review papers describing novel, green approaches applied to the design of biomaterials, ranging from the nano- to the macro-scale.

Potential topics include, but are not limited to, the following:

  • Green processes for biomaterials production;
  • Supercritical CO2;
  • Freeze-drying;
  • Nanoparticles;
  • Nanosomes;
  • Nanomedicine;
  • Aerogels;
  • Modeling of drug release from nanocarriers;
  • Machine learning applied to the biomedical field.

Prof. Dr. Lucia Baldino
Guest Editor

Manuscript Submission Information

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Keywords

  • nanotechnology
  • liposomes
  • niosomes
  • transfersomes
  • nanoparticles
  • aerogels
  • biomaterials
  • nanomedicine
  • supercritical CO2
  • freeze-drying

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Published Papers (2 papers)

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Research

17 pages, 3581 KB  
Article
β-Cyclodextrin-Grafted Polypyrrole–Rhodamine B Nanoplatforms for Drug Delivery and Image-Guided Photothermal Therapy In Vitro
by Shasha Hong, Yuan Jiao, Ruyu Li, Peng Lei, Chuan Dong, Shang Guo and Shaomin Shuang
Materials 2025, 18(23), 5313; https://doi.org/10.3390/ma18235313 - 25 Nov 2025
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Abstract
Synergetic therapeutic study using multifunctional nanoplatforms has been developed as an innovative modality for effective cancer treatment to improve the clinical efficiency of anticancer drugs and reduce severe off-target side effects. Herein, an artificial nanoplatform (denoted as PPy-RhB-PDA-CD-LA) was prepared by grafting β-cyclodextrin [...] Read more.
Synergetic therapeutic study using multifunctional nanoplatforms has been developed as an innovative modality for effective cancer treatment to improve the clinical efficiency of anticancer drugs and reduce severe off-target side effects. Herein, an artificial nanoplatform (denoted as PPy-RhB-PDA-CD-LA) was prepared by grafting β-cyclodextrin (β-CD) derivatives and lactobionic acid (LA) on the surface of rhodamine B (RhB)-doped polypyrrole nanoparticles (PPy-RhB NPs) using polydopamine (PDA) as the intermediate linker. Doxorubicin (DOX) was selected and successfully loaded onto the nanoplatforms with a high loading content of 327 mg/g. Furthermore, significant NIR light-triggered release of DOX was observed in a weak acidic tumor microenvironment. The nanoplatform exhibited superior photostability with a high photothermal effect of 51.7% under irradiation by a 808 nm laser and a competent temperature sensitivity (SR is 1.44% °C−1) under a single wavelength excitation. MTT assay against SMMC-7721 cells clearly illustrated that the nanoplatform had low cytotoxicity at a high level (200 μg/mL) after 24 h and high therapeutic efficacy of chemo-phototherapy. Thus, it is highly promising for use in biomedical applications. Full article
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21 pages, 4257 KB  
Article
Synthesis and Characterization of Curcumin-Polycaprolactone Block Copolymers for Biomedical Applications
by Qianqian Wei, Adam Junka, Bartlomiej Dudek, Houman Alimoradi, Julia Simińska-Stanny, Lei Nie, Oseweuba Valentine Okoro and Armin Shavandi
Materials 2025, 18(18), 4348; https://doi.org/10.3390/ma18184348 - 17 Sep 2025
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Abstract
Polycaprolactone (PCL) is widely utilized in biomedical applications such as tissue engineering and drug delivery; however, its limited bioactivity remains a key challenge. In this study, bioactive curcumin–polycaprolactone block copolymers (MCP) were synthesized via ring-opening polymerization of ε-caprolactone and maleic anhydride modified curcumin. [...] Read more.
Polycaprolactone (PCL) is widely utilized in biomedical applications such as tissue engineering and drug delivery; however, its limited bioactivity remains a key challenge. In this study, bioactive curcumin–polycaprolactone block copolymers (MCP) were synthesized via ring-opening polymerization of ε-caprolactone and maleic anhydride modified curcumin. The resulting MCP was characterized using FTIR, 1H NMR, UV–Vis spectroscopy, and differential scanning calorimetry (DSC). It demonstrated enhanced antioxidant activity, UV-blocking capacity, and electro spinnability compared to PCL. Electrospun MCP films exhibited improved biocompatibility and promoted fibroblast migration. Furthermore, composite films incorporating MCP into a PVA matrix with and without copper or iron were evaluated for in vivo toxicity and antimicrobial activity. These formulations showed no systemic or contact toxicity in the Galleria mellonella model, confirming their biocompatibility. Films containing copper or iron exhibited selective anti-Pseudomonas aeruginosa activity and low but reproducible antioxidant capacity. This study highlights the multifunctionality and biomedical potential of MCP and its composites as tunable platforms for regenerative and antimicrobial applications. Full article
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