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Novel Nanosystems Composed of Amphiphilic Copolymers: Synthesis, Properties and Some Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Polymeric Materials".

Deadline for manuscript submissions: closed (1 December 2023) | Viewed by 2206

Special Issue Editors


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Guest Editor
Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
3. Faculty of Medicine, Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; micelleplexes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Amphiphilic copolymers are versatile tools with a wide range of practical applications, e.g., in the environment, cosmetics, pharmacy, and medicine, among others.

Particularly, they have revealed interesting properties to be used for the repurposing of drug design and development for medicinal purposes, from a patient-centric perspective. In fact, amphiphilic copolymers have been interestingly applied for the development of innovative nanosystems, namely polymeric micelles, polymersomes, hydrogels, and dendrimers, to develop artificial biomimetic membranes. Most of the amphiphilic copolymers that have been studied for medicinal purposes have been advantageously recognized to be biocompatible with the potential to be modified for a targeted/triggering release to the disease site.

This Special Issue aims to compile the most recent advances in the synthesis, characterization, and applications of amphiphilic copolymers for medicinal purposes, taking into consideration a sustainable and safety-by-design.

Therefore, we cordially invite researchers to contribute with original research work or review articles that present up-to-date data on the use of amphiphilic copolymers for the prevention and management of human health.

Dr. Ivana Jarak
Dr. Cátia Domingues
Dr. Ana Figueiras
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amphiphilic copolymers
  • nanomedicine
  • polymeric micelles
  • polymersomes
  • biomimetic membranes
  • dendrimers
  • green synthesis
  • safety-by-design

Published Papers (1 paper)

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Review

36 pages, 2816 KiB  
Review
Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications
by Mariana Fonseca, Ivana Jarak, Francis Victor, Cátia Domingues, Francisco Veiga and Ana Figueiras
Materials 2024, 17(2), 319; https://doi.org/10.3390/ma17020319 - 08 Jan 2024
Cited by 2 | Viewed by 1869
Abstract
Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed of hydrophobic and hydrophilic blocks. They can encapsulate hydrophilic molecules in the aqueous core and hydrophobic molecules within the membrane. The composition of block copolymers can be tuned, enabling [...] Read more.
Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed of hydrophobic and hydrophilic blocks. They can encapsulate hydrophilic molecules in the aqueous core and hydrophobic molecules within the membrane. The composition of block copolymers can be tuned, enabling control of characteristics and properties of formed polymersomes and, thus, their application in areas such as drug delivery, diagnostics, or bioimaging. The preparation methods of polymersomes can also impact their characteristics and the preservation of the encapsulated drugs. Many methods have been described, including direct hydration, thin film hydration, electroporation, the pH-switch method, solvent shift method, single and double emulsion method, flash nanoprecipitation, and microfluidic synthesis. Considering polymersome structure and composition, there are several types of polymersomes including theranostic polymersomes, polymersomes decorated with targeting ligands for selective delivery, stimuli-responsive polymersomes, or porous polymersomes with multiple promising applications. Due to the shortcomings related to the stability, efficacy, and safety of some therapeutics in the human body, polymersomes as drug delivery systems have been good candidates to improve the quality of therapies against a wide range of diseases, including cancer. Chemotherapy and immunotherapy can be improved by using polymersomes to deliver the drugs, protecting and directing them to the exact site of action. Moreover, this approach is also promising for targeted delivery of biologics since they represent a class of drugs with poor stability and high susceptibility to in vivo clearance. However, the lack of a well-defined regulatory plan for polymersome formulations has hampered their follow-up to clinical trials and subsequent market entry. Full article
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