The Power of GRAS Natural Compounds in Nanomedicine and Health

Dear Colleagues,

Worldwide, cancer continues to represent a leading cause of morbidity and death. Despite the advances in diagnosis and therapy, namely by the advent of immunotherapy, many patients continue to be diagnosed late or are unresponsive to conventional treatments. Therefore, the identification of novel biomarkers and the development of personalized-based treatments are ultimately needed to address challenges in cancer treatment. Based on these, natural compounds that are Generally Recognized as Safe (GRAS) have become attractive players as they can selectively act at the mitochondria level inducing oxidative stress and cancer cell death.

Besides these, natural compounds have appealing properties for Nanomedicine applications such as the delivery of drugs or imaging agents for a target/triggering cancer diagnosis, monitoring, and treatment. Furthermore, the application of nanoparticles or engineered antibodies to deliver natural compounds has also been explored for selective tumor targeting.

This Special Issue aims to compile the most recent advances in the application of natural compounds in drug development and their potential applications in nanomedicine and advanced therapies, specifically against cancer. Therefore, we cordially invite researchers to disclose original research work or review manuscripts that present up-to-date data on the use of natural compounds for the prevention and management of human health.

Dr. Cátia Domingues
Dr. Ana Figueiras
Dr. Ivana Jarak
Guest Editors

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• advanced therapies
• cancer
• flavonoids
• HPLC
• metabolomics
• nanomedicine
• nanoparticles
• natural compounds
• oxidative stress
• phenolic acids
• ROS