Natural Products from the Beibu Gulf of the South China Sea

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3890

Special Issue Editors


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Guest Editor
Institute of Marine Drugs, Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, China
Interests: marine natural products; secondary metabolites
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Marine Drugs, Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, China
Interests: marine natural products

E-Mail Website
Guest Editor
Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
Interests: marine natural product chemistry; drug leads; pharmacological mechanism; marine microorganisms; biotransformation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Beibu Gulf (Gulf of Tonkin) is located in the northwestern South China Sea. Vietnam lies to the west of the gulf, while China’s Guangxi Province and Hainan Island lie to the north and east of the gulf, respectively. This gulf harbors four representative marine ecosystems, including a coral reef, a mangrove forest, a seagrass bed, and coastal wetland ecosystems; these are rich in gas, oil, and biological resources, particularly where there is an abundant biodiversity of marine (micro-)organisms. There are few reports (< 150 references) on marine natural product (MNP) research in the Beibu Gulf. To our knowledge, approximately 1200 MNPs, including 500 novel ones, have been obtained from the Beibu Gulf (predominantly polyketides, terpenes, and alkaloids); these untapped and abundant biological resources could attract considerable interest from MNP chemists and marine biologists in the coming decades.

This Special Issue will focus on the investigation of novel and bioactive substances from the Beibu Gulf, including the following aspects:

  • Structurally new and bioactive natural products from marine macro- and microorganisms;
  • Structures and functions of marine biomacromolecules;
  • Efficacy and pharmacological mechanisms of MNPs;
  • Total synthesis, optimization or biosynthesis of bioactive or novel MNPs;
  • Marine medicinal biological resources research.

Dr. Xiaowei Luo
Prof. Dr. Chenghai Gao
Prof. Dr. Xuefeng Zhou
Guest Editors

Manuscript Submission Information

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Keywords

  • Beibu Gulf
  • marine natural products
  • marine biomacromolecules
  • marine bioactive compounds
  • biosynthetic pathway
  • pharmacological mechanism
  • marine biological resources

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Published Papers (1 paper)

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Review

54 pages, 5279 KiB  
Review
Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity
by Yukang Gao, Jianjian Wang, Pornphimon Meesakul, Jiamin Zhou, Jinyan Liu, Shuo Liu, Cong Wang and Shugeng Cao
Mar. Drugs 2024, 22(2), 70; https://doi.org/10.3390/md22020070 - 28 Jan 2024
Cited by 3 | Viewed by 2985
Abstract
Marine fungi, such as species from the Penicillium and Aspergillus genera, are prolific producers of a diversity of natural products with cytotoxic properties. These fungi have been successfully isolated and identified from various marine sources, including sponges, coral, algae, mangroves, sediment, and seawater. [...] Read more.
Marine fungi, such as species from the Penicillium and Aspergillus genera, are prolific producers of a diversity of natural products with cytotoxic properties. These fungi have been successfully isolated and identified from various marine sources, including sponges, coral, algae, mangroves, sediment, and seawater. The cytotoxic compounds derived from marine fungi can be categorized into five distinct classes: polyketides, peptides, terpenoids and sterols, hybrids, and other miscellaneous compounds. Notably, the pre-eminent group among these compounds comprises polyketides, accounting for 307 out of 642 identified compounds. Particularly, within this collection, 23 out of the 642 compounds exhibit remarkable cytotoxic potency, with IC50 values measured at the nanomolar (nM) or nanogram per milliliter (ng/mL) levels. This review elucidates the originating fungal strains, the sources of isolation, chemical structures, and the noteworthy antitumor activity of the 642 novel natural products isolated from marine fungi. The scope of this review encompasses the period from 1991 to 2023. Full article
(This article belongs to the Special Issue Natural Products from the Beibu Gulf of the South China Sea)
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