Special Issue "Marine Compounds from the Far Eastern Organisms"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Sergey A. Dyshlovoy
Website
Guest Editor
1 Laboratory of Pharmacology, A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
2 Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3 Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Interests: marine natural compounds; secondary metabolites; anticancer activity; mechanism of action; autophagy; drug combinational studies
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Dr. Timofey V. Malyarenko

Guest Editor
1 G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
2 School of Natural Science, Far Eastern Federal University, Vladivostok, Russia
Interests: bioorganic chemistry; chemistry of natural and physiologically active compounds; steroids; sea stars; secondary metabolites
Dr. Olesya I. Zhuravleva

Guest Editor
1 School of Natural Science, Far Eastern Federal University, Vladivostok, Russia
2 G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
Interests: natural products chemistry; bioactive compounds from marine fungi; secondary metabolites
Dr. Maxim E. Zhidkov

Guest Editor
School of Natural Sciences, Far Eastern Federal University, Vladivostok, Russian Federation
Interests: medicinal chemistry; total synthesis of natural products; marine alkaloids; organic chemistry; mechanisms of organic reactions

Special Issue Information

Dear Colleagues,

The term “Far East” implies a huge geographical region that consists of Eastern Russia, and Eastern and Southeastern Asia, and includes the waters of two oceans—the Pacific and Indian. Over 20 countries are considered to be part of this region, many of which have access to the sea, and therefore are actively involved in the research of the marine inhabitants and its metabolites. Compounds isolated from Far Eastern organisms are a significant and very important part of the whole pool of marine-derived substances—both new and previously known—bearing a unique chemical structure as well as an impressive spectrum of promising biological activities.

The Special Issue “Marine Compounds from the Far Eastern Organisms” of Marine Drugs will cover the whole scope of the molecules, both novel and previously characterized, isolated from the marine organisms inhabiting the Far Eastern region. This Special Issue is focused on the structure elucidation, chemistry, and diversity, as well as the various biological activities of these compounds. We are looking forward to interesting manuscripts related to this exciting topic!

Dr. Sergey A. Dyshlovoy
Dr. Timofey V. Malyarenko
Dr. Olesya I. Zhuravleva
Dr. Maxim E. Zhidkov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Far East
  • Pacific Ocean
  • Indian ocean
  • marine natural products
  • metabolites
  • isolation
  • structure
  • biological activity

Published Papers (1 paper)

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Research

Open AccessArticle
N-Docosahexaenoylethanolamine Attenuates Neuroinflammation and Improves Hippocampal Neurogenesis in Rats with Sciatic Nerve Chronic Constriction Injury
Mar. Drugs 2020, 18(10), 516; https://doi.org/10.3390/md18100516 - 15 Oct 2020
Abstract
Chronic neuropathic pain is a condition that causes both sensory disturbances and a variety of functional disorders, indicating the involvement of various brain structures in pain pathogenesis. One of the factors underlying chronic neuropathic pain is neuroinflammation, which is accompanied by microglial activation [...] Read more.
Chronic neuropathic pain is a condition that causes both sensory disturbances and a variety of functional disorders, indicating the involvement of various brain structures in pain pathogenesis. One of the factors underlying chronic neuropathic pain is neuroinflammation, which is accompanied by microglial activation and pro-inflammatory factor release. N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endocannabinoid-like metabolite synthesized endogenously from docosahexaenoic acid. Synaptamide exhibits anti-inflammatory activity and improves neurite outgrowth, neurogenesis, and synaptogenesis within the hippocampus. This study aims to evaluate the effects of synaptamide obtained by the chemical modification of DHA, extracted from the Far Eastern raw material Berryteuthis magister on neuroinflammatory response and hippocampal neurogenesis changes during neuropathic pain. The study of microglial protein and cytokine concentrations was performed using immunohistochemistry and ELISA. The brain lipid analysis was performed using the liquid chromatography-mass spectrometry technique. Behavioral experiments showed that synaptamide prevented neuropathic pain-associated sensory and behavioral changes, such as thermal allodynia, impaired locomotor activity, working and long-term memory, and increased anxiety. Synaptamide attenuated microglial activation, release of proinflammatory cytokines, and decrease in hippocampal neurogenesis. Lipid analysis revealed changes in the brain N-acylethanolamines composition and plasmalogen concentration after synaptamide administration. In conclusion, we show here that synaptamide may have potential for use in preventing or treating neuropathic cognitive pain and emotional effects. Full article
(This article belongs to the Special Issue Marine Compounds from the Far Eastern Organisms)
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