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Article

New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia
2
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, 690000 Vladivostok, Russia
3
Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
4
Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia
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Laboratory of Experimental Oncology, Department of Oncology, University Medical Center Hamburg-Eppendorf, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, 20246 Hamburg, Germany
6
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Mar. Drugs 2021, 19(1), 32; https://doi.org/10.3390/md19010032
Received: 16 December 2020 / Revised: 25 December 2020 / Accepted: 4 January 2021 / Published: 12 January 2021
(This article belongs to the Special Issue Marine Compounds from the Far Eastern Organisms)
Seven new deoxyisoaustamide derivatives (17) together with known compounds (810) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 46 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%. View Full-Text
Keywords: Penicillium dimorphosporum; secondary metabolites; prenylated indole diketopiperazines; deoxyisoaustamide; neuroprotective activity; paraquat Penicillium dimorphosporum; secondary metabolites; prenylated indole diketopiperazines; deoxyisoaustamide; neuroprotective activity; paraquat
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MDPI and ACS Style

Zhuravleva, O.I.; Antonov, A.S.; Trang, V.T.D.; Pivkin, M.V.; Khudyakova, Y.V.; Denisenko, V.A.; Popov, R.S.; Kim, N.Y.; Yurchenko, E.A.; Gerasimenko, A.V.; Udovenko, A.A.; Amsberg, G.v.; Dyshlovoy, S.A.; Afiyatullov, S.S. New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689. Mar. Drugs 2021, 19, 32. https://doi.org/10.3390/md19010032

AMA Style

Zhuravleva OI, Antonov AS, Trang VTD, Pivkin MV, Khudyakova YV, Denisenko VA, Popov RS, Kim NY, Yurchenko EA, Gerasimenko AV, Udovenko AA, Amsberg Gv, Dyshlovoy SA, Afiyatullov SS. New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689. Marine Drugs. 2021; 19(1):32. https://doi.org/10.3390/md19010032

Chicago/Turabian Style

Zhuravleva, Olesya I., Alexandr S. Antonov, Vo T.D. Trang, Mikhail V. Pivkin, Yuliya V. Khudyakova, Vladimir A. Denisenko, Roman S. Popov, Natalya Y. Kim, Ekaterina A. Yurchenko, Andrey V. Gerasimenko, Anatoly A. Udovenko, Gunhild v. Amsberg, Sergey A. Dyshlovoy, and Shamil S. Afiyatullov 2021. "New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689" Marine Drugs 19, no. 1: 32. https://doi.org/10.3390/md19010032

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