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Marine Drugs
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Bioactive Secondary Metabolites from Marine Fungi and Actinomycetes
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Bioactive Secondary Metabolites from Marine Fungi and Actinomycetes

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2508

Special Issue Editor

Prof. Dr. Hee Jae Shin

E-Mail Website
Guest Editor
Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea
Interests: marine natural products; biomedical applications; drug discovery; anticancer compounds; anti-inflammatory compounds; antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine fungi and actinomycetes represent prolific yet underexplored sources of structurally diverse and biologically potent secondary metabolites. Adaptation to unique marine environments has endowed these microorganisms with extraordinary biosynthetic capabilities, yielding natural products with promising anticancer, antimicrobial and anti-inflammatory properties and metabolic disease-related advantages.

This Special Issue aims to highlight recent advances in the discovery, structure elucidation, biosynthesis, and biological evaluation of bioactive secondary metabolites from marine-derived fungi and actinomycetes. We particularly welcome studies integrating chemical analysis with biological, genomic, and pharmacological approaches.

We invite original research articles, short communications, and reviews that contribute to a deeper understanding of marine microbial natural products and their translational potential in drug discovery.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • marine fungi
  • marine actinomycetes
  • secondary metabolites
  • drug discovery
  • anticancer compounds
  • antimicrobial agents
  • anti-inflammatory agents

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Published Papers (2 papers)

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Research

15 pages, 2034 KB  
Article
Chlokamycins B–D: Chlorohydrin-Containing Polycyclic Tetramate Macrolactams with Cytotoxic Activity from the Marine Sponge-Derived Streptomyces xiamenensis 1310KO-148
by Min Ah Lee, Jong Soon Kang, Joo-Hee Kwon, Jeong-Wook Yang, Hwa-Sun Lee, Chang-Su Heo and Hee Jae Shin
Mar. Drugs 2026, 24(3), 117; https://doi.org/10.3390/md24030117 - 21 Mar 2026
Viewed by 1423
Abstract
Chemical investigation of the marine sponge-derived Streptomyces xiamenensis 1310KO-148 afforded six polycyclic tetramate macrolactams (PTMs), including three known compounds (1–3) and three previously undescribed chlorohydrin-containing analogues, chlokamycins B–D (4–6). Their planar structures were elucidated by [...] Read more.
Chemical investigation of the marine sponge-derived Streptomyces xiamenensis 1310KO-148 afforded six polycyclic tetramate macrolactams (PTMs), including three known compounds (1–3) and three previously undescribed chlorohydrin-containing analogues, chlokamycins B–D (4–6). Their planar structures were elucidated by extensive analysis of 1D and 2D NMR spectra and HR-ESIMS data, while the relative configurations were assigned using NOESY correlations. The absolute configurations were further confirmed by electronic circular dichroism (ECD) calculations. Compounds 3–6 exhibited significant cytotoxic activity against 14 human cancer cell lines (GI50 = 2.68–24.92 μM) and antibacterial activity against Staphylococcus aureus (MIC = 16.00–32.00 μg/mL) and Micrococcus luteus (MIC = 4.00–32.00 μg/mL) among six tested bacterial strains. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites from Marine Fungi and Actinomycetes)
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15 pages, 2198 KB  
Article
Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation
by Guangli Deng, Wu Ruan, Qun Li, Qingyun Peng, Yunan Liu, Lingbin Lin, Yuan Li, Qianqian Shen, Yangrong Zhao, Junfeng Wang, Yi Chen and Ming-Wei Wang
Mar. Drugs 2026, 24(3), 108; https://doi.org/10.3390/md24030108 - 13 Mar 2026
Viewed by 710
Abstract
Nine new mycophenolic acid derivatives, penicacids O–W (1–9), two first-time reported natural products (10, 11), and five known compounds (12–16), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a [...] Read more.
Nine new mycophenolic acid derivatives, penicacids O–W (1–9), two first-time reported natural products (10, 11), and five known compounds (12–16), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher’s methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC50 values ranged from nM to μM levels. Compounds 5, 7–9 showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC50 values between 0.13 and 1.13 μM. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites from Marine Fungi and Actinomycetes)
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