Solubility and Solubilization of Drugs: Modeling and Thermodynamic Analysis

Dear Colleagues,

Solubility is one of the most important physicochemical properties in the research and development of pharmaceutical products since it affects their biopharmaceutical and pharmacokinetic characteristics. In this context, this Special Issue focuses on the development of strategies that improve the solubility of an active pharmaceutical ingredient (API), such as the use of cosolvents, surfactants, physical modification of the API, pH control, complex formation, and the use of co-solutes; these are some of the most relevant lines of research in pharmaceutical sciences presently.

In this context, understanding the energetic phenomena involved in the dissolution process allows understanding of the possible molecular interactions involved to be developed which, in turn, could facilitate the development of more rational and efficient design processes. In this way, the development of mathematical models, as well as the simulation of phenomena, have been consolidated as relevant research subjects in the area of solubility.

It is expected that this Special Issue will compile the experiences of different experts in the area, consolidating a document that, in addition to presenting the most recent advances in the subject of drug solubility, allows the subject to be theorized and the fundamental concepts of this topic to be strengthened.

Prof. Dr. Daniel Ricardo Delgado
Guest Editor

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