Sirtuins in Mammalian Reproduction: Involvement in Physiological and Disease States

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3856

Special Issue Editors


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Guest Editor
Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel
Interests: reproductive endocrinology; ovarian follicle; corpus luteum; angiogenesis hypoxia

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Guest Editor
Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10-748 Olsztyn, Poland
Interests: reproductive endocrinology; prostaglandins; PPARs; miRNAs; sirtuins; epigenetic regulation; ovary; embryo-endometrial interactions; polycystic ovary syndrome

Special Issue Information

Dear Colleagues,

Sirtuins are widely recognized for their roles in metabolic homeostasis and aging. Encouraged by novel advances, we plan a Special Issue that will give an overview of the most recent developments in sirtuin research in the field of reproductive biology.

We are soliciting high-impact research articles (with reviews consisting up to 30%) to this Special Issue entitled “Sirtuins in mammalian reproduction: involvement in physiological and disease states”. Potential topics include, but are not limited to: sirtuins’ actions, mechanisms of action, and signaling pathways; and the regulation of their expression in gonadal tissues and cells, germ cells and endometrium during the reproductive cycle, aging process, and disease states such as PCOS and reproductive malignancies. Both in vivo and in vitro studies in different organisms and models are welcomed.

Prof. Dr. Rina Meidan
Dr. Magdalena Szymanska
Guest Editors

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Published Papers (1 paper)

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Review

14 pages, 2346 KiB  
Review
SIRT1: A Key Player in Male Reproduction
by Muhammad Babar Khawar, Abdullah Muhammad Sohail and Wei Li
Life 2022, 12(2), 318; https://doi.org/10.3390/life12020318 - 21 Feb 2022
Cited by 11 | Viewed by 3018
Abstract
Reproduction is the way to immortality for an individual, and it is essential to the continuation of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis, age-related problems, and sexual reproduction. Sirtuin 1 (SIRT1) belongs to the sirtuin family of deacetylases, [...] Read more.
Reproduction is the way to immortality for an individual, and it is essential to the continuation of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis, age-related problems, and sexual reproduction. Sirtuin 1 (SIRT1) belongs to the sirtuin family of deacetylases, and it is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase. It removes the acetyl group from a variety of substrates. SIRT1 regulates endocrine/metabolic, reproductive, and placental development by deacetylating histone, different transcription factors, and signal transduction molecules in a variety of cellular processes. It also plays a very important role in the synthesis and secretion of sex hormones via regulating the hypothalamus-pituitary-gonadal (HPG) axis. Moreover, SIRT1 participates in several key stages of spermatogenesis and sperm maturation. The current review will give a thorough overview of SIRT1’s functions in male reproductive processes, thus paving the way for more research on restorative techniques and their uses in reproductive medicine. Full article
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