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Life
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Antioxidants—Oxidative Stress and Antioxidative Mechanism in Plants
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Antioxidants—Oxidative Stress and Antioxidative Mechanism in Plants

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Plant Science".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6638

Special Issue Editor

Dr. Simona Carmen Liţescu

E-Mail Website
Guest Editor
National Institute for Research Development of Biological Sciences, Centre of Bioanalysis, 060031 Bucharest, Romania
Interests: antioxidants and antioxidative mechanism; free radicals associated toxicity; biochemistry; biocompatible nanomaterials; ecology

Special Issue Information

Dear Colleagues,

Antioxidants are the main defense of living organisms against cellular oxidative damage initiated by free radicals. Free radicals occur as a result of either normal metabolism or oxidative stress produced by environmental conditions, and accumulation of a high level of free radicals can generate cell damage and even DNA damage in the absence of antioxidants that are capable to quench them. Antioxidative mechanisms are highly specific; plants have a complex antioxidative system, including both enzymatic and nonenzymatic compounds, explicitly expressed during plants’ lifecycle since they are exposed to various environmental stress-inducing sources. Comprehension of antioxidants’ involvement in mechanisms of reactive oxygen species regulation is important in order to modulate the conditions ensuring normal plant growth. It is worth mentioning that, at the same time, plants are the main source of antioxidants used in human nutrition, and they are currently widely used in nutrition of precision. Therefore, studies on the role of antioxidant supplements, as well as the role of gene variability in oxidative stress in relation to nutrigenomics are welcome.

In this Special Issue, we shall present state-of-the-art knowledge around antioxidants and their role in regulation mechanisms of oxidative stress in plants and humans through classic and/or molecular genetic assessment, as well as their beneficial role in human nutrition.

Dr. Simona Carmen Liţescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • free radical cellular mechanisms
  • antioxidative mechanisms
  • assessing methods

Published Papers (2 papers)

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Research

14 pages, 1226 KiB  
Article
Renoprotection of Selected Antioxidant-Rich Foods (Water Spinach and Red Grape) and Probiotics in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats
by Sneha Sarwar, Md. Jamal Hossain, Nafis Md. Irfan, Tamima Ahsan, Md. Saidul Arefin, Arebia Rahman, Abdullah Alsubaie, Badr Alharthi, Mayeen Uddin Khandaker, David A. Bradley, Talha Bin Emran and Sheikh Nazrul Islam
Life 2022, 12(1), 60; https://doi.org/10.3390/life12010060 - 3 Jan 2022
Cited by 16 | Viewed by 2737
Abstract
Objectives: The current study investigated the curative effects of two selected antioxidant-rich foods (water spinach and red grape) and probiotics on the kidney exposed to nephrotoxicity induced by gentamicin. Methods: A total of 30 Wistar Albino female rats equally divided into six groups [...] Read more.
Objectives: The current study investigated the curative effects of two selected antioxidant-rich foods (water spinach and red grape) and probiotics on the kidney exposed to nephrotoxicity induced by gentamicin. Methods: A total of 30 Wistar Albino female rats equally divided into six groups were studied for seven days. Except for the normal control (NC) group, all groups received 80 mg/kg/day gentamicin (GEN) injection intra-peritoneally for seven days. NC and GEN groups received only regular diet. In the water spinach group (GEN + WS) and red grape (GEN + RG) groups, rats were provided with 20 g/rat/day of boiled water spinach and 5 mL/rat/day of red grape juice, respectively. The probiotic (GEN + P4) and (GEN + P8) groups received 4 × 109 and 8 × 109 viable bacteria, respectively. On the 8th day, all the rats were sacrificed to collect blood and kidney. Serum creatinine, urea, uric acid, malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) were analyzed. In addition, kidney histopathology was taken for final observation. Results: Both antioxidant-rich foods and probiotic (P4) significantly (p < 0.05) attenuated the GEN-induced oxidative and nitrosative stress and improved kidney function by lowering uremic toxin (serum creatinine, and uric acid) levels. Histopathological findings of kidney tissues of all groups were consistent with the biochemical findings. Conclusion: The current preclinical study suggests that the consumption of antioxidant-rich foods might be a promising fighting option against gentamycin-induced nephrotoxicity and oxidative stress. However, extensive studies and clinical monitoring are immediately required to determine the appropriate probiotic doses and mechanism of action for such effects. Full article
(This article belongs to the Special Issue Antioxidants—Oxidative Stress and Antioxidative Mechanism in Plants)
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11 pages, 531 KiB  
Article
Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters with a High-Cholesterol Diet
by Hao-Hsiang Chang, Yi-Chan Lan, Shiu-Dong Chung and Chiang-Ting Chien
Life 2021, 11(8), 802; https://doi.org/10.3390/life11080802 - 9 Aug 2021
Cited by 6 | Viewed by 3147
Abstract
Nutritional strategies to reduce hyperlipidemia and the risk of cardiovascular disease are gaining more public favor and medical professionals’ attention. The authors of this study explored the effect of sweet potato leaf powder (SPLP) feeding on the parameters of plasma lipids, reactive oxygen [...] Read more.
Nutritional strategies to reduce hyperlipidemia and the risk of cardiovascular disease are gaining more public favor and medical professionals’ attention. The authors of this study explored the effect of sweet potato leaf powder (SPLP) feeding on the parameters of plasma lipids, reactive oxygen species, and time to thrombosis formation in Syrian hamsters fed with high-cholesterol diets. The animals were separated into six groups: a feeding control diet, a control diet containing 0.1% cholesterol, a control diet containing 0.2% cholesterol, a control diet containing 0.1% cholesterol plus 2.5% SPLP, a control diet containing 0.1% cholesterol plus 5% SPLP, and a control diet containing 0.2% cholesterol plus 5% SPLP for six weeks. The levels of serum total cholesterol (51% increase), low-density lipoprotein cholesterol (70.6% increase), very-low-density lipoprotein cholesterol (51.3% increase), and the triglyceride and atherogenic index (LDL-C/HDL-C) significantly increased in the high-cholesterol diet groups. Concomitant 5% sweet potato leaf powder ingestion significantly decreased the lipid profiles, with a 20.6% total cholesterol reduction in the 0.1% cholesterol diet groups, a 17.2% reduction in the 0.2% group, a 48.7% LDL reduction in the 0.1% cholesterol group, and a 30.3% reduction in the 0.2% group, with a consequent decrease in the atherogenic index. SPLP feeding was found to be associated with increased fecal sterol contents, with a 188.6% increase in the 0.1% cholesterol-fed group and a 177.3% increase in the 0.2% group. The SPLP-fed groups had depressed ROS levels, elongated FeCl3-induced times to thrombosis formation, and increased liver superoxide dismutase contents and SREBP-1 protein expression. Sweet potato leaf intake could reduce plasma total cholesterol, LDL, and oxidative stress. We suggest sweet potato leaf intake as a choice of nutritional strategy for hyperlipidemia and cardiovascular disease prevention. Full article
(This article belongs to the Special Issue Antioxidants—Oxidative Stress and Antioxidative Mechanism in Plants)
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