Insulin Resistance in Polycystic Ovary Syndrome

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: closed (25 December 2021) | Viewed by 7496

Special Issue Editor


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Guest Editor
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan
Interests: polycystic ovary syndrome; high-risk pregnancy; gynecological minimally invasive surgery

Special Issue Information

Dear Colleagues,

Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries on ultrasonography. In addition, PCOS is frequently associated with insulin resistance, accompanied by compensatory hyperinsulinemia, which has been reported to increase the risk of developing type 2 diabetes mellitus as compared with weight-matched women serving as controls. Many studies demonstrated that insulin resistance is a key contributor to metabolic disturbance and is a key role in the pathogenesis of PCOS. There are many ways to treat or improve the impairment of insulin sensitivity in PCOS. Loss of body weight (BW) and life-style modifications are highly recommended as the first line of treatment in PCOS. Insulin-sensitizing agents such as metformin and rosiglitazone have recently been suggested as a tool for the treatment of insulin resistance in PCOS. Controlled studies have shown that metformin administration, by promoting bodyweight loss, can decrease fasting and stimulated plasma insulin levels.

This Special Issue seeks studies focused on the insulin resistance of PCOS, including the mechanism of insulin resistance, treatment, and conceptual approaches to the topic.

Dr. Kok Min Seow
Guest Editor

Keywords

insulin resistance

polycystic ovary syndrome

laparoscopic ovarian drilling

hyperinsulinemia

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Published Papers (1 paper)

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19 pages, 1244 KiB  
Systematic Review
Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-Analysis
by Chan-Hee Kim and Seon-Heui Lee
Life 2022, 12(2), 308; https://doi.org/10.3390/life12020308 - 18 Feb 2022
Cited by 28 | Viewed by 6880
Abstract
(1) Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrine disorders among women of reproductive age. Previous studies have employed lifestyle interventions to manage anovulatory infertility and endocrine disorders. However, the effect of lifestyle interventions on the [...] Read more.
(1) Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrine disorders among women of reproductive age. Previous studies have employed lifestyle interventions to manage anovulatory infertility and endocrine disorders. However, the effect of lifestyle interventions on the metabolic index remains ambiguous; (2) Methods: Data were obtained through a systematic search of the Ovid-Medline, Ovid-EMBASE, and Cochrane Library databases. Two reviewers independently reviewed the literature in two stages. A consensus was achieved through discussions regarding the final selection of the literature; (3) Results: This study observed that the group that underwent lifestyle modifications displayed significant improvement in reproductive function compared to the control group. Combination therapy with diet and exercise resulted in improved fasting insulin levels, compared to monotherapy with diet or exercise. Moreover, moderate weight loss (a minimum of 5%) resulted in an improved metabolic index. The subgroup analysis revealed that the group that underwent lifestyle modifications had a significantly higher number of patients with improved menstrual cycles, compared to the control groups; (4) Conclusions: Lifestyle modification using combination therapy is a promising therapeutic approach that can be employed in the management of PCOS patients with obesity. This scenario warrants further studies with larger sample sizes to develop ideal treatment protocols. Full article
(This article belongs to the Special Issue Insulin Resistance in Polycystic Ovary Syndrome)
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