Extremophiles Breakthrough: Hot Topics and Current Issues in Their Isolation, Identification and Biotechnological Applications—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 27 March 2026 | Viewed by 788

Special Issue Editors


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Guest Editor
Division of Microbiology, Faculty of Biology, Ludwig-Maximilians-Universität München, 82152 Martinsried, Germany
Interests: extremophiles; Thermus thermophilus; arsenic-resistance systems; genome editing tools; synthetic biology; β-amino acids
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Guest Editor Assistant
Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio Acton, 55, 80133 Naples, Italy
Interests: extremophiles; agri-food residues; green and blue biotechnology; synthetic biology; fermentation

Special Issue Information

Dear Colleagues,

Over the last few decades, the study of extremophiles has led to many discoveries that are useful in understanding how life evolved in particular ecological niches, as many enzymes derived from extremophilic microorganisms have had significant impacts on our lifestyle. The search for new extremophiles is crucial not only from an ecological point of view but also from a biotechnological point of view. Extremophiles are considered to be factories of high-value molecules that are able to retain their biological activities under harsh conditions, often employed in industrial processes. Moreover, recent studies have focused on the exploitation of these microorganisms for the isolation of enzymes to be used for sustainable bio-energy and bio-fuel production. As the Guest Editors of this Special Issue, we are pleased to invite you to submit your cutting-edge research articles and reviews related to extremophiles.

Dr. Martina Aulitto
Dr. Giovanni Gallo
Guest Editors

Dr. Emanuela Maresca
Guest Editor Assistant

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Keywords

  • astrobiology
  • biochemistry and molecular biology
  • biodiversity and ecology
  • biotechnology
  • extraterrestrial analogs
  • extreme environments
  • extremophiles
  • genetics, genomics, and proteomics
  • origin of life
  • phylogeny and evolution
  • physiology and metabolism

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Published Papers (1 paper)

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Review

25 pages, 2132 KB  
Review
Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness
by Emanuela Maresca, Micaela Carbone, Giovanni Gallo, Salvatore Fusco and Martina Aulitto
Life 2025, 15(12), 1787; https://doi.org/10.3390/life15121787 - 21 Nov 2025
Viewed by 573
Abstract
The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin health through both topical and systemic approaches. Extremophile microorganisms, adapted to extreme conditions, produce unique compounds such as ectoine, extremozymes, carotenoids, exopolysaccharides (EPSs), and mycosporine-like amino [...] Read more.
The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin health through both topical and systemic approaches. Extremophile microorganisms, adapted to extreme conditions, produce unique compounds such as ectoine, extremozymes, carotenoids, exopolysaccharides (EPSs), and mycosporine-like amino acids (MAAs). These molecules exhibit antioxidant, anti-inflammatory, photoprotective, and regenerative properties. This review analyzes the molecular adaptations that enable extremophiles to synthesize these compounds, and explores their cosmetic applications, including enzymatic exfoliation, UV protection, hydration, and anti-pollution effects. This paper examines their nutraceutical potential, highlighting systemic benefits such as improved skin elasticity, reduced photoaging, and modulation of the gut–skin axis via prebiotic EPSs. Industrial strategies for sustainable production, such as microbial fermentation, synthetic biology, and green extraction, are discussed. Examples of commercial ingredients like PlusXanthin™, Antarctic-G, and Desertica. Extremophile-derived ingredients combine biological efficacy with environmental sustainability, positioning them as key assets for next-generation skincare. Future directions include clinical validation, regulatory harmonization, and the development of personalized, microbiome-friendly formulations. Full article
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